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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/375

Title: Repeated-measures models to evaluate a hepatitis B vaccination program
Authors: Renard, Didier
Bruckers, Liesbeth
Molenberghs, Geert
Vellinga, Akke
Van Damme, Pierre
Keywords: Longitudinal data
Infectious diseases
Issue Date: 2001
Publisher: JOHN WILEY
Citation: Statistics in Medicine, 20(6). p. 951-963
Abstract: In 1985-1986, a hepatitis B vaccination programme was conducted in a Belgian institution for the mentally handicapped. A group of 97 residents was followed up for 11 years in order to characterize the long-term persistence of hepatitis B antibodies after vaccination. This paper proposes the use of linear mixed-effects models to account for serial correlation and between-individual heterogeneity in the data, while adjusting the analysis for various individual characteristics and important risk factors in the response to vaccination. We propose several model building strategies and focus on the prediction of future levels of antibodies.
URI: http://hdl.handle.net/1942/375
DOI: 10.1002/sim.699
ISI #: 000167670800010
ISSN: 0277-6715
Category: A1
Type: Journal Contribution
Validation: ecoom, 2002
Appears in Collections: Research publications

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