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|Title: ||ANTIBODY-BINDING PROFILE OF PURIFIED AND CELL-BOUND CD26 - DESIGNATION OF BT5/9 AND TA5.9 TO THE CD26 CLUSTER|
|Authors: ||DEMEESTER, I|
|Issue Date: ||1993|
|Publisher: ||GUSTAV FISCHER VERLAG|
|Citation: ||IMMUNOBIOLOGY, 188(1-2). p. 145-158|
|Abstract: ||The CD26 activation antigen (Ag) which is expressed on a subpopulation of human T cells has been characterized as dipeptidyl peptidase IV (DPP IV, EC 184.108.40.206). In this paper, we describe the antibody binding profile of CD26/DPP IV, purified from human peripheral blood lymphocytes. The purified molecule binds to the anti-Ta1, anti-1F7 and anti-134-2C2 monoclonal antibodies (mAb), reported to react with cell-bound CD26 Ag. Among unclustered mAb recognizing T cell antigens, two, anti-BT5/9 and anti-TA5.9 were found to react with purified and cell-bound CD26 Ag. The classification of the BT5/9 Ag, the functional properties of the BT5/9+ T cell subset, as well as the in vivo effect of anti-BT5/9 mAb administration, are re-interpreted in the light of its specificity. Applying the anti-TA5.9 mAb in three color FACS analyses, we demonstrated that CD26+bright cells co-express CD45RO but not HLA-DR and CD38.|
|Notes: ||INST TROP MED PRINCE LEOPOLD,PATHOL & IMMUNOL LAB,B-2000 ANTWERP,BELGIUM. DR WILLEMS INST,DIEPENBEEK,BELGIUM. EUROGENET,TESSENDERLO,BELGIUM. UNIV GENOA,IST TUMORI,I-16126 GENOA,ITALY.DEMEESTER, I, UNIV INSTELLING ANTWERP,DEPT MED BIOCHEM,BLDG S-6,UNIV PLEIN 1,B-2610 WILRIJK,BELGIUM.|
|ISI #: ||A1993LJ99500013|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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