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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3694

Title: Absolute number and percentage of circulating natural-killer, non-mhc-restricted t-cytotoxic, and phagocytic-cells in unipolar depression
Authors: Maes, Michael
LAMBRECHTS, J
SUY, E
VANDERVORST, Carine
BOSMANS, E
Issue Date: 1994
Publisher: KARGER
Citation: NEUROPSYCHOBIOLOGY, 29(4). p. 157-163
Abstract: One of the most consistently reported immunological abnormalities in major depression is blunted ex vivo natural killer cell activity (NKCA). This study was designed to investigate the number and percentage of circulating natural killer cells (NKC) in a group of patients with unipolar depression. In addition, the number and percentage of other phagocytic/cytotoxic cells were determined. The following cell subsets were investigated: number of leukocytes, monocytes, neutrophils, lymphocytes, NKC (CD16(+) or CD56(+)), and non-MHC-restricted cytotoxic T lymphocytes (CTL) in 17 healthy controls and 79 depressed subjects. There were no differences either in absolute number or percentage of NKC, or CTL between healthy controls, minor, simple major, and melancholic depressed subjects. Depression per se was characterized by a leukocytosis due to monocytosis and neutrophilia. Our results do not support the thesis that depression-related blunted NKCA is caused by a decreased number or percentage of NKC in peripheral blood.
Notes: PSYCHIAT CTR WEYBURN,MUNSTERBILZEN,BELGIUM. UNIV DIEPENBEEK,DR WILLEMS INST,DIEPENBEEK,BELGIUM. EUROGENET,TESSENDERLO,BELGIUM.MAES, M, UNIV CLEVELAND HOSP,DEPT PSYCHIAT,BIOL PSYCHIAT LAB,HANNA PAVIL,ROOM B-68,2040 ABINGTON RD,CLEVELAND,OH 44106.
URI: http://hdl.handle.net/1942/3694
ISI #: A1994NP33600001
ISSN: 0302-282X
Type: Journal Contribution
Appears in Collections: Research publications

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