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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3678

Title: MYELIN BASIC PROTEIN-REACTIVE T-CELLS IN MULTIPLE-SCLEROSIS - PATHOLOGICAL RELEVANCE AND THERAPEUTIC TARGETING
Authors: Zhang, J
RAUS, Jef
Issue Date: 1994
Publisher: KLUWER ACADEMIC PUBL
Citation: CYTOTECHNOLOGY, 16(3). p. 181-187
Abstract: Autoreactive T cells specific for myelin proteins, such as myelin basic protein (MBP), are thought to play an important role in the pathogenesis of multiple sclerosis (MS). In MS, these MBP-reactive T cells are activated and clonally expanded in vivo and found to accumulate in the brain compartment, suggesting their pathologic role in the disease. There is experimental evidence supporting the beliefs that MBP-reactive T cells are regulated in vivo by the clonotypic regulatory network. This concept has led to the paradigm of T cell vaccination where attenuated MBP-reactive T cells are used as vaccines to effectively prevent and treat experimental autoimmune encephalomyelitis, an animal model for MS. In this paper, the recent evidence regarding the pathologic relevance of MBP-reactive T cell in MS is reviewed. In particular, we discuss our recent clinical trial in which patients with MS were vaccinated with inactivated autologous MBP-reactive T cell clones to investigate the nature of clonotypic responses in vivo, and whether the responses are effective in depleting circulating MBP-reactive T cells in patients with MS. Our study presented in this paper demonstrated the successful depletion of MBP-reactive T cells by T cell vaccination and touched upon important issues related to the clinical application of T cell vaccination in humans. This review provides new insights into the current development in designing effective therapeutic strategies, such as T cell vaccination, to treat patients with MS and other autoimmune diseases.
Notes: LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.ZHANG, JW, DR L WILLEMS INST,MULTIPLE SCLEROSIS & IMMUNOL UNIT,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3678
ISI #: A1994QQ56600007
ISSN: 0920-9069
Type: Journal Contribution
Appears in Collections: Research publications

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