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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3666

Title: OPIOID ANTAGONIST AFFECTS BEHAVIORAL-EFFECTS OF EXPOSURE IN-VIVO
Authors: Arntz, A.
Merckelbach, H.
DEJONG, P
Issue Date: 1993
Publisher: AMER PSYCHOLOGICAL ASSOC
Citation: JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 61(5). p. 865-870
Abstract: This study tested the hypothesis that endogenous opioids are involved in the extinction of phobic fear through exposure in vivo. Forty-eight spider phobics participated in a 2-hr therapist-directed exposure in vivo treatment. Sixteen Ss were assigned to placebo, 16 to a low dose of naltrexone, and 16 to a high dose of naltrexone. Before intervention, after treatment, and at a 1-wk follow-up test, self-report, physiological, and behavioral measures of phobic fear were completed. At 1-wk follow-up, naltrexone was significantly related, in a dose-dependent way, to a greater relapse on avoidance measures but not on emotional, cognitive, and physiological measures. Endogenous opioids may be specifically involved in the extinction of avoidance behavior but not in the extinction of all aspects of phobic fear.
Notes: LIMBURGS UNIV CENTRUM,DEPT MENTAL HLTH SCI,6200 MD MAASTRICHT,NETHERLANDS.ARNTZ, A, LIMBURGS UNIV CENTRUM,DEPT MED PSYCHOL,POB 616,6200 MD MAASTRICHT,NETHERLANDS.
URI: http://hdl.handle.net/1942/3666
ISI #: A1993MC03800018
ISSN: 0022-006X
Type: Journal Contribution
Appears in Collections: Non-affiliated authors

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