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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3654

Title: THE DIRECT RENAL TUBULAR EFFECT OF ANGIOTENSIN-II IN CHICKEN
Authors: CUYPERS, Y
McConaghey, P.
STEELS, Paul
Issue Date: 1993
Publisher: KARGER
Citation: RENAL PHYSIOLOGY AND BIOCHEMISTRY, 16(6). p. 325-332
Abstract: Taking advantage of the particular renal vascular arrangement in cocks, angiotensin II was injected (0.12-0.96 mu g/min) into the portal system of one kidney in order to increase the angiotensin-II concentration in the physiological nanomolar range at the level. of the renal tubules. Angiotensin II induced an increase in blood pressure of 5% and a bilateral rise in glomerular filtration rate and effective renal plasma now of 28 and 22%, respectively. The urine volume increased five times on the infused side and three times on the control side. The Na+ excretion increased 14 times on the infused side and only seven times on the control side. During angiotensin infusion, the fractional water excretion was 4.9% on the infused side and 2.9% on th e control side versus 1.1 and 1.2% during the control period. For the fractional Na+ excretion, the respective values were 2 and 1.2% versus 0.2 and 0.2% during the control period. The differences between the two kidneys demonstrate the direct tubular action of angiotensin II, inhibiting the tubular Na+ and water reabsorption at physiological nanomolar concentrations. Angiotensin seems thus to play an important intrarenal role.
Notes: LIMBURGS UNIV CENTRUM,FYSIOL LAB,B-3390 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3654
ISI #: A1993MJ67300004
ISSN: 1011-6524
Type: Journal Contribution
Appears in Collections: Research publications

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