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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3625

Title: T-cell vaccination in multiple-sclerosis - hopes and facts
Authors: Zhang, JK
RAUS, Jef
Issue Date: 1994
Publisher: ACTA MEDICA BELGICA
Citation: ACTA NEUROLOGICA BELGICA, 94(2). p. 112-115
Abstract: Six MS-patients were inoculated three times with autologous attenuated MBP-specific T cell clones at two month intervals. No toxic effects were observed. After the third inoculation the precursor frequency of the MBP-specific T cells dropped to undetectable levels in all patients. Injection of attenuated MBP-specific T cells gave rise to a pronounced response of anti-clonotypic T cells and a limited anti-ergotypic response. The anti-clonotypic T cells proliferated in the presence of the vaccine clones and were inhibitory and cytotoxic for the same vaccine clones. This clinical trial shows for the first time that antigen specific T cell vaccination in humans is feasible. The results obtained are highly promising for future treatments of Multiple Sclerosis and other autoimmune diseases.
Notes: LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM.ZHANG, JW, DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3625
Link to publication: http://www.actaneurologica.be/acta/article.asp?lang=en&navid=137&id=464&mod=acta
ISI #: A1994NU94600007
ISSN: 0300-9009
Type: Journal Contribution
Appears in Collections: Research publications

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