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|Title: ||Plasma-membrane-Bound mcromoleculas are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?|
|Authors: ||Vereb, G.|
|Issue Date: ||1995|
|Publisher: ||JOHN WILEY & SONS LTD|
|Citation: ||JOURNAL OF MOLECULAR RECOGNITION, 8(4). p. 237-246|
|Abstract: ||Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level.|
|Notes: ||UNIV MED SCH DEBRECEN,DEPT BIOPHYS,H-4012 DEBRECEN,HUNGARY. CHRISTIE HOSP NATL HLTH SERV TRUST,CANC RES CAMPAIGN,PATERSON INST CANC RES,MANCHESTER M20 9BX,LANCS,ENGLAND. INRCA ANCONA,DEPT GERONTOL & GERIAT,CTR CITOL,ANCONA,ITALY. LIMBURGS UNIV CTR,PHYSIOL RES GRP,B-3590 DIEPENBEEK,BELGIUM.|
|ISI #: ||A1995TF18900001|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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