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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3593

Title: Plasma-membrane-Bound mcromoleculas are dynamically aggregated to form non-random codistribution patterns of selected functional elements. Do pattern recognition processes govern antigen presentation and intercellular interactions?
Authors: Vereb, G.
Matyus, L.
Bene, L.
Panyi, G.
Bacso, Z.
Balazs, M.
Matko, J.
Szollosi, J.
Gaspar, R.
Damjanovich, S.
Dale, Robert
Pieri, C.
Ameloot, Marcel
Issue Date: 1995
Publisher: JOHN WILEY & SONS LTD
Citation: JOURNAL OF MOLECULAR RECOGNITION, 8(4). p. 237-246
Abstract: Molecular recognition processes between cell surface elements are discussed with special reference to cell surface pattern formation of membrane-bound integral proteins. The existence, as detected by flow cytometric resonance energy transfer (Appendix), and significance of cell surface patterns involving the interleukin-2 receptor, the T-cell receptor-CD3 system, the intercellular adhesion molecule ICAM-1, and the major histocompatibility complex class I and class II molecules in the plasma membrane of lymphocytes are described. The modulation of antigen presentation by transmembrane potential changes is discussed, and a general role of transmembrane potential changes, and therefore of ion channel activities, adduced as one of the major regulatory mechanisms of cell-cell communication. A general role in the mediation and regulation of intercellular interactions is suggested for cell-surface macromolecular patterns. The dynamic pattern of protein and lipid molecules in the plasma membrane is generated by the genetic code, but has a remarkable flexibility and may be one of the major instruments of accommodation and recognition processes at the cellular level.
Notes: UNIV MED SCH DEBRECEN,DEPT BIOPHYS,H-4012 DEBRECEN,HUNGARY. CHRISTIE HOSP NATL HLTH SERV TRUST,CANC RES CAMPAIGN,PATERSON INST CANC RES,MANCHESTER M20 9BX,LANCS,ENGLAND. INRCA ANCONA,DEPT GERONTOL & GERIAT,CTR CITOL,ANCONA,ITALY. LIMBURGS UNIV CTR,PHYSIOL RES GRP,B-3590 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3593
DOI: 10.1002/jmr.300080402
ISI #: A1995TF18900001
ISSN: 0952-3499
Type: Journal Contribution
Appears in Collections: Research publications

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