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|Title: ||SUPERANTIGEN REACTIVITY OF GAMMA-DELTA T-CELL CLONES ISOLATED FROM PATIENTS WITH MULTIPLE-SCLEROSIS AND CONTROLS|
|Authors: ||STINISSEN, Piet|
|Issue Date: ||1995|
|Publisher: ||ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS|
|Citation: ||CELLULAR IMMUNOLOGY, 166(2). p. 227-235|
|Abstract: ||gamma delta T cells have been implicated as playing a role in the demyelinating processes of multiple sclerosis (MS). However, the nature of the ligands which lead to activation and accumulation of gamma delta T cells in the brain lesions remains unknown. This study was undertaken to examine whether gamma delta T cells derived from cerebrospinal fluid and blood of MS patients could be stimulated by bacterial superantigens: staphylococcal enterotoxins A and B and toxic shock syndrome toxin-1. A panel of 16 gamma delta T cell clones isolated from MS patients and controls was found to react with the superantigens used at a nanogram range and displayed specific cytotoxic activity toward target cells pulsed with the corresponding superantigens. The responses of the gamma delta T cell clones did not require MHC-matched accessory cells and were not blocked by antibodies to the MHC molecules, suggesting a non-MHC restricted interaction. The superantigen reactivity was associated with both V delta 2(+)/V gamma 2(+) and V delta 1(+)/V gamma 1(+) subsets, reportedly found in the MS lesions. Our data suggest an alternative pathway which may account for gamma delta T cell activation in MS. (C) 1995 Academic Press, Inc.|
|Notes: ||DR WILLEMS INST,BIOTECHNOL UNIT,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM.STINISSEN, P, DR WILLEMS INST,MULTIPLE SCLEROSIS RES & IMMUNOL UNIT,DIEPENBEEK,BELGIUM.|
|ISI #: ||A1995TK31300007|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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