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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3590

Title: SUPERANTIGEN REACTIVITY OF GAMMA-DELTA T-CELL CLONES ISOLATED FROM PATIENTS WITH MULTIPLE-SCLEROSIS AND CONTROLS
Authors: STINISSEN, Piet
VANDEVYVER, Caroline
RAUS, Jef
Zhang, JK
Issue Date: 1995
Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Citation: CELLULAR IMMUNOLOGY, 166(2). p. 227-235
Abstract: gamma delta T cells have been implicated as playing a role in the demyelinating processes of multiple sclerosis (MS). However, the nature of the ligands which lead to activation and accumulation of gamma delta T cells in the brain lesions remains unknown. This study was undertaken to examine whether gamma delta T cells derived from cerebrospinal fluid and blood of MS patients could be stimulated by bacterial superantigens: staphylococcal enterotoxins A and B and toxic shock syndrome toxin-1. A panel of 16 gamma delta T cell clones isolated from MS patients and controls was found to react with the superantigens used at a nanogram range and displayed specific cytotoxic activity toward target cells pulsed with the corresponding superantigens. The responses of the gamma delta T cell clones did not require MHC-matched accessory cells and were not blocked by antibodies to the MHC molecules, suggesting a non-MHC restricted interaction. The superantigen reactivity was associated with both V delta 2(+)/V gamma 2(+) and V delta 1(+)/V gamma 1(+) subsets, reportedly found in the MS lesions. Our data suggest an alternative pathway which may account for gamma delta T cell activation in MS. (C) 1995 Academic Press, Inc.
Notes: DR WILLEMS INST,BIOTECHNOL UNIT,DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,DIEPENBEEK,BELGIUM.STINISSEN, P, DR WILLEMS INST,MULTIPLE SCLEROSIS RES & IMMUNOL UNIT,DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3590
DOI: 10.1006/cimm.1995.9975
ISI #: A1995TK31300007
ISSN: 0008-8749
Type: Journal Contribution
Appears in Collections: Research publications

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