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|Title: ||Activation and clonal expansion of human myelin basic protein-reactive t-cells by bacterial superantigens|
|Authors: ||Zhang, JK|
|Issue Date: ||1995|
|Publisher: ||ACADEMIC PRESS (LONDON) LTD|
|Citation: ||JOURNAL OF AUTOIMMUNITY, 8(4). p. 615-632|
|Abstract: ||Autoreactive T cells specific for myelin basic protein (MBP) are part of the normal T cell repertoire and are present both in patients with multiple sclerosis (MS) and healthy individuals. There is evidence suggesting in vivo activation and persistent clonal expansion of MBP-reactive T cells in MS. This study was undertaken to investigate the potential role of bacterial superantigens (SA) in the activation of MBP-reactive T cells. Twenty-seven MBP-reactive T cell clones generated from 10 MS patients and one normal individual were examined for reactivity to SA, in association with their T cell receptor V beta gene usage. The majority of the clones responded to at least one of the SA tested, staphylococcal enterotoxins (SEA and SEB) and toxic shock syndrome toxin-1 (TSST-1). The clones reactive to SEA and SEB expressed various V beta genes while T cell reactivity to TSST-1 correlated with the V beta 2 expression. Furthermore, circulating MBP-reactive T cells could be expanded from lymphocyte cultures primarily exposed to respective SA in more than 50% of MS patients and normal individuals tested. However, activation and expansion of circulating MBP-reactive T cells by SA was not directly associated with the disease. This study lends support to the potential role of SA in the activation of MBP-reactive T cells and suggests that an altered regulatory mechanism may account for further expansion and persistence of MBP-reactive T cells in MS. (C) 1995 Academic Press Limited|
|Notes: ||DR WILLEMS INST,MULTIPLE SCLEROSIS RES & IMMUNOL UNIT,B-3590 DIEPENBEEK,BELGIUM. LIMBURGS UNIV CENTRUM,B-3590 DIEPENBEEK,BELGIUM. ACAD ZIEKENHUIS,TISSUE TYPING LAB,MAASTRICHT,NETHERLANDS.ZHANG, JW, DR WILLEMS INST,BIOTECHNOL UNIT,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.|
|ISI #: ||A1995RR95700012|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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