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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3555

Title: DEPLETION OF MYELIN-BASIC-PROTEIN AUTOREACTIVE T-CELLS BY T-CELL VACCINATION - PILOT TRIAL IN MULTIPLE-SCLEROSIS
Authors: MEDAER, Rob
STINISSEN, Piet
RAUS, Jef
Zhang, JK
TRUYEN, L
Issue Date: 1995
Publisher: LANCET LTD
Citation: LANCET, 346(8978). p. 807-808
Abstract: In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete circulating MBP-reactive T cells. In the 2 years before and after vaccination, exacerbations decreased in five vaccinated patients (numbers 1, 2, 6-8) with relapsing-remitting disease from sixteen to three, respectively, and from twelve to ten in their matched controls. Magnetic resonance imaging showed a mean 8.0% increase in brain lesion size in the vaccinated patients compared with a 39.5% increase in the controls. Lesions and/or relapses worsened in three cases after Vaccination in association with reappearance of circulating MBP-reactive T cells.
Notes: FREE UNIV AMSTERDAM,ACAD HOSP,DEPT DIAGNOST RADIOL,AMSTERDAM,NETHERLANDS. CLIN DE MICK,MULTIPLE SCLEROSIS REHABIL UNIT,BRASSCHAAT,BELGIUM.MEDAER, R, LIMBURGS UNIV CENTRUM,DR L WILLEMS INST,MULTIPLE SCLEROSIS RES & IMMUNOL UNIT,B-3590 DLEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3555
DOI: 10.1016/S0140-6736(95)91622-9
ISI #: A1995RW25800013
ISSN: 0099-5355
Type: Journal Contribution
Appears in Collections: Research publications

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