Document Server@UHasselt >
Research publications >
Please use this identifier to cite or link to this item:
|Title: ||DEPLETION OF MYELIN-BASIC-PROTEIN AUTOREACTIVE T-CELLS BY T-CELL VACCINATION - PILOT TRIAL IN MULTIPLE-SCLEROSIS|
|Authors: ||MEDAER, Rob|
|Issue Date: ||1995|
|Publisher: ||LANCET LTD|
|Citation: ||LANCET, 346(8978). p. 807-808|
|Abstract: ||In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete circulating MBP-reactive T cells. In the 2 years before and after vaccination, exacerbations decreased in five vaccinated patients (numbers 1, 2, 6-8) with relapsing-remitting disease from sixteen to three, respectively, and from twelve to ten in their matched controls. Magnetic resonance imaging showed a mean 8.0% increase in brain lesion size in the vaccinated patients compared with a 39.5% increase in the controls. Lesions and/or relapses worsened in three cases after Vaccination in association with reappearance of circulating MBP-reactive T cells.|
|Notes: ||FREE UNIV AMSTERDAM,ACAD HOSP,DEPT DIAGNOST RADIOL,AMSTERDAM,NETHERLANDS. CLIN DE MICK,MULTIPLE SCLEROSIS REHABIL UNIT,BRASSCHAAT,BELGIUM.MEDAER, R, LIMBURGS UNIV CENTRUM,DR L WILLEMS INST,MULTIPLE SCLEROSIS RES & IMMUNOL UNIT,B-3590 DLEPENBEEK,BELGIUM.|
|ISI #: ||A1995RW25800013|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.