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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3524

Title: NANDROLONE DECANOATE - PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC USE IN OSTEOPOROSIS
Authors: GEUSENS, Piet
Issue Date: 1995
Publisher: ROYAL BELG RHEUMATOL SOC
Citation: CLINICAL RHEUMATOLOGY, 14(S3). p. 32-39
Abstract: The therapeutic profile on bone of nandrolone decanoate is that of inhibitor of bone resorption with temporary increase in bone formation, followed by an absence of suppression of bone formation, indicating uncoupling of bone resorption and formation. This results is an increase in bone mineral content at the proximal and distal radius, and in some patients at the lumbar spine. Furthermore, nandrolone decanoate increases calcium balance and muscle mass, diminishes vertebral pain and increases the mobility of the spine. Virilization occurred in around 50% of the patients (mainly hoarseness and/or hirsutism), and 9% of the patients dropped out because of this reason. A dose of 50 mg every 3 to 4 weeks is indicated in the treatment of osteoporosis in women, especially when they have low muscle mass, associated debilitating disease, and in patients with corticosteroid induced osteoporosis. It should only be prescribed after the age of 65 to 75 years to minimize the occurrence of clinical adverse effects and to increase its tolerability, which is higher in this group, Although some effects are reported on fracture rate, insufficient prospective data are available.
Notes: GEUSENS, P, LIMBURGS UNIV CENTRUM,DR WILLEMS INST,B-3590 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3524
DOI: 10.1007/BF02210686
ISI #: A1995RY71500008
ISSN: 0770-3198
Type: Journal Contribution
Appears in Collections: Research publications

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