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|Title: ||Placental uptake and transfer of environmental chemicals relating to allergy in childhood years: PLUTOCRACY|
|Authors: ||NAMBUUSI, Betty|
|Advisors: ||ASSAM NKOUIBERT, P.|
|Issue Date: ||2007|
|Abstract: ||The primary objectives of the study were to investigate whether neonatal (cord blood) cytokines and
maternal cytokines at delivery were predictive biomarkers of allergic outcomes in children at
18 months of age, and also to evaluate if allergy outcome in the child is affected by the pollutants.
The secondary objective was to assess the effect of pollutants on immune status of the mother,
placenta cytokines, cord blood cytokines and child cytokines.
Multiple regression models, Multiple logistic regression models and Multivariate logistic regression
models were fitted to the data. Further, Receiver Operating Characteristic curves were used to
determine the predictive ability of cord blood cytokines, maternal cytokines and pollutants for
A model cumulating allergies disclosed that, increased levels of sum of Organochlorine insecticides
in breast milk (BM-sum3), Lead in placenta (Pbplacenta) and il4hacord cytokines increase the
probability of manifesting atleast one of the allergies. Higher levels of the sum of Organochlorine
insecticides in placenta (PLAT-sum3) and Lead in maternal blood serum (Pbblood) reduce chances
of manifesting atleast one allergy in child. The probability of manifesting atleast one allergy is
predicted by variables region, il4hacord, BM-sum3, Pbplacenta, PLAT-sum3 and Pbblood.
Multivariate models revealed that, higher levels of il4phacord, il5phacord, il10phacord and
INFgmaternal increase the probability of manifesting all four allergies. In the presence of
Phadinhalant, children in Slovakia have a lower probability of having all allergies than children in
Belgium. Elevated levels of INFgphamaternal in the maternal blood serum increase the probability
of developing all four allergies in the absence of Phadinhalant. Increased concentrations of
Cadmium in placenta, sum of Organochlorine insecticides in maternal blood and sum of
Organochlorine insecticides in breast milk increase the probability of developing all four allergies.
Higher levels of Lead in maternal blood serum, sum of Chlorinated benzenes in maternal blood
serum, sum of PCBs in breast milk, sum of PCBs in maternal blood serum and sum of PCBs in
placenta reduce the probability of developing all four allergies.
Multivariate models confirmed that cytokines il4phacord, il5phacord and il10phacord predict
Atopic eczema. Also, INFgphamaternal cytokines and country predict food allergies and Atopic
eczema. Lead in maternal blood serum, sum of PCBs in placenta, sum of PCBs in breast milk, sum
of Organochlorine insecticides in breast milk, sum of PCBs in maternal blood serum, Cadmium in
placenta and sum of Organochlorine insecticides in maternal blood serum predict Atopic eczema in
|Notes: ||Master in Biostatistics|
|Type: ||Theses and Dissertations|
|Appears in Collections: ||Applied Statistics: Master theses|
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