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|Title: ||Polymers for colon specific drug delivery|
|Authors: ||Schacht, E|
|Issue Date: ||1996|
|Publisher: ||ELSEVIER SCIENCE BV|
|Citation: ||JOURNAL OF CONTROLLED RELEASE, 39(2-3). p. 327-338|
|Abstract: ||Azo-linked polymeric prodrugs of 5-aminosalicylic acid (5-ASA) were prepared and evaluated in simulated human intestinal microbial ecosystem. Release of 5-ASA was demonstrated. Polyamides containing azo groups in the backbone were prepared and tested in vitro in a reductive buffer or in the bioreactor medium. It was demonstrated that for the hydrophobic polymer reduction stops at the hydrazine stage whereas for a hydrophilic analogue reduction with formation of amines occurred.|
|Notes: ||MICROBIAL ECOL LAB,B-9000 GHENT,BELGIUM. UNIV LIMBURG,MAT RES INST,B-3590 DIEPENBEEK,BELGIUM.Schacht, E, STATE UNIV GHENT,BIOMAT & POLYMER RES GRP,KRIJGSLAAN 281,B-9000 GHENT,BELGIUM.|
|ISI #: ||A1996UT43200022|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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