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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3446

Title: Immunosuppressors inhibit voltage-gated potassium channels in human peripheral blood lymphocytes
Authors: Panyi, G
Gaspar, R
Krasznai, Z
ter Horst, JJ
AMELOOT, Marcel
Aszalos, A.
STEELS, Paul
Damjanovich, S
Issue Date: 1996
Publisher: ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Citation: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 221(2). p. 254-258
Abstract: The effects of immunosuppressive agents on the potassium current of human peripheral blood lymphocytes have been studied using the whole-cell patch-clamp technique. Cyclosporin A(10 mu g/ml), rapamycin (10 mu g/ml) and FK-506 (2.5 mu g/ml) reduced the peak K+ current by approximately 40, 30 and 40% of the control, respectively, without any change in the reversal potential of the current. The current inhibition was similar at all membrane potentials studied and was accompanied with an increase in the rate of K+ current inactivation Membrane potential measurements in current-clamp showed a marked depolarization of the membrane (>10 mV) upon the addition of either immunosuppressor to the cells. Our findings revealed that the voltage-dependent potassium current in human peripheral blood lymphocytes is inhibited by Cyclosporin A and other immunosuppressors, resulting in a depolarized membrane potential. (C) 1996 Academic Press, Inc.
Notes: DEBRECEN UNIV MED,SCH MED,DEPT BIOPHYS,H-4102 DEBRECEN,HUNGARY. LIMBURGS UNIV CENTRUM,DEPT PHYSIOL,DIEPENBEEK,BELGIUM. US FDA,DIV RES & TESTING,WASHINGTON,DC 20204.
URI: http://hdl.handle.net/1942/3446
DOI: 10.1006/bbrc.1996.0582
ISI #: A1996UF91100008
ISSN: 0006-291X
Type: Journal Contribution
Appears in Collections: Research publications

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