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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3375

Title: Causal inference in a placebo-controlled clinical trial with binary outcome and ordered compliance
Authors: Goetghebeur, Els
Molenberghs, Geert
Issue Date: 1996
Publisher: AMER STATIST ASSN
Citation: JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 91(435). p. 928-934
Abstract: We propose a likelihood-based method to analyze the causal effect of partial compliance (i.e., unplanned partial exposure to treatment or placebo) in the LRC-CPPT data, a prevention trial with long term follow-up previously analyzed by Efron and Feldman. Initially, we construct ordered compliance categories and dichotomize response. Assuming increased exposure to cholestyramine does not increase cholesterol, we estimate exposure-response curves in different compliance subsets. Subjects in different arms with similar levels of compliance to the assignment may have a different placebo prognosis (i.e., success probability under a possible zero exposure level). The sole assumption that the placebo group reflects response to zero exposure for the treatment group as a whole allows estimation of a causal parameter in a special case only. When a single parameter represents the association between responses to possible treatment exposures and treatment compliance, simple estimates are derived for a set of causal parameters. The example is analyzed in detail, and more general applicability and extensions of the method are discussed.
Notes: LIMBURGS UNIV CTR,BIOSTAT RES UNIT,B-3590 DIEPENBEEK,BELGIUM.Goetghebeur, E, UNIV LIMBURG,METHODOL & STAT UNIT,PB 616,NL-6200 MD MAASTRICHT,NETHERLANDS.
URI: http://hdl.handle.net/1942/3375
DOI: 10.2307/2291711
ISI #: A1996VK23300002
ISSN: 0162-1459
Type: Journal Contribution
Appears in Collections: Research publications

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