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|Title: ||Prospects for T cell vaccination in multiple sclerosis|
|Authors: ||MEDAER, Rob|
|Issue Date: ||1997|
|Publisher: ||ADIS INTERNATIONAL LTD|
|Citation: ||BIODRUGS, 8(1). p. 1-5|
|Abstract: ||Accumulating evidence indicates that multiple sclerosis, a chronic inflammatory disease of the central nervous system, has an autoimmune origin. Since T cells reactive to myelin basic protein (MBP) are thought to play an important role in the pathogenesis of this disease, it was assumed that inactivation or depletion of this pathogenic T cell subset may have therapeutic effects in multiple sclerosis. We have recently reported that T cell vaccination, i.e. immunisation with attenuated autologous MBP-reactive T cell clones, leads to the depletion of the MBP-reactive T cells. Furthermore, this approach induced favourable clinical effects in the treated patients, encouraging further studies of T cell vaccination in multiple sclerosis.|
|Notes: ||LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM.Medaer, R, DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.|
|ISI #: ||A1997XJ48500001|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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