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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3283

Title: Prospects for T cell vaccination in multiple sclerosis
Authors: MEDAER, Rob
STINISSEN, Piet
Zhang, JW
RAUS, Jef
Issue Date: 1997
Publisher: ADIS INTERNATIONAL LTD
Citation: BIODRUGS, 8(1). p. 1-5
Abstract: Accumulating evidence indicates that multiple sclerosis, a chronic inflammatory disease of the central nervous system, has an autoimmune origin. Since T cells reactive to myelin basic protein (MBP) are thought to play an important role in the pathogenesis of this disease, it was assumed that inactivation or depletion of this pathogenic T cell subset may have therapeutic effects in multiple sclerosis. We have recently reported that T cell vaccination, i.e. immunisation with attenuated autologous MBP-reactive T cell clones, leads to the depletion of the MBP-reactive T cells. Furthermore, this approach induced favourable clinical effects in the treated patients, encouraging further studies of T cell vaccination in multiple sclerosis.
Notes: LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM.Medaer, R, DR L WILLEMS INST,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3283
ISI #: A1997XJ48500001
ISSN: 1173-8804
Type: Journal Contribution
Appears in Collections: Research publications

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