www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3269

Title: Risks of multiple sclerosis in relatives of patients in Flanders, Belgium
Authors: Carton, H
Vlietinck, R
Debruyne, J
DeKeyser, J
DHooghe, MB
Loos, R
MEDAER, Rob
Truyen, L
Yee, IML
Sadovnick, AD
Issue Date: 1997
Publisher: BRITISH MED JOURNAL PUBL GROUP
Citation: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 62(4). p. 329-333
Abstract: Objectives - To calculate age adjusted risks for multiple sclerosis in relatives of Flemish patients with multiple sclerosis. Methods - Lifetime risks were calculated using the maximum likelihood approach. Results - Vital information was obtained on 674 probands with multiple sclerosis in Flanders and a total of their 26 225 first, second, and third degree relatives. Full medical information to allow documentation of multiple sclerosis status was available for 21 351 (81.4%) relatives. The age adjusted risk for parents was 1.61 (SEM 0.35)%, for siblings 2.10 (SE 0.36)%, and for children 1.71 (SEM 0.70)%. For aunts and uncles, the risk was 0.66 (SEM 0.13)%. Conclusions - The risk for first degree relatives of patients with multiple sclerosis in Flanders is increased 10-fold to 12-fold; for second degree relatives, it is increased threefold. This information can be used for risk counselling in families and provides additional support for the role of more than one locus contributing to the susceptibility of multiple sclerosis.
Notes: CATHOLIC UNIV LEUVEN,CTR HUMAN GENET,B-3000 LOUVAIN,BELGIUM. STATE UNIV GHENT HOSP,DEPT NEUROL,B-9000 GHENT,BELGIUM. FREE UNIV BRUSSELS,DEPT NEUROL,BRUSSELS,BELGIUM. UNIV ANTWERP HOSP,DEPT NEUROL,ANTWERP,BELGIUM. MS CTR MELSBROEK,MELSBROEK,BELGIUM. DWI,DIEPENBEEK,BELGIUM. UNIV BRITISH COLUMBIA,DEPT MED GENET,VANCOUVER,BC V5Z 1M9,CANADA.
URI: http://hdl.handle.net/1942/3269
Link to publication: http://jnnp.bmj.com/cgi/content/abstract/62/4/329
ISI #: A1997WR27900004
ISSN: 0022-3050
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.