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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3252

Title: Quadriceps and grip strength are related to vitamin D receptor genotype in elderly nonobese women
Authors: GEUSENS, Piet
VANDEVYVER, Caroline
VANHOOF, Johan
Cassiman, JJ
Boonen, S
RAUS, Jef
Issue Date: 1997
Publisher: BLACKWELL SCIENCE INC
Citation: JOURNAL OF BONE AND MINERAL RESEARCH, 12(12). p. 2082-2088
Abstract: Osteoporotic fragility fractures are related to bone density and injury, which are both related to muscle strength, The influence of genetic factors, such as the vitamin D receptor (VDR) polymorphism on bone mineral density (BMD), is documented but still controversial, and is not known for muscle strength, In the present study, we investigated the association between the VDR BsmI polymorphism and BMD (femoral neck FN], lumbar spine [LS],and proximal forearm [FA]) and muscle strength (quadriceps and grip strength) in 501 healthy women older than 70 years. No association was found between the VDR genotypes and BMD in elderly women. However, in nonobese women (body mass index <30 kg/cm(2)), the BMD in the FN was 5% higher in women with the bb BsmI genotype than in women with the BE genotype (p < 0.05), After correction for muscle strength, no association was found, A significant association between the VDR genotypes and quadriceps and grip strength was observed. In nonobese women, a 23% difference in quadriceps strength (p < 0.01) and 7% in grip strength (NS) was observed between the bb and BE genotype of the VDR, After correction for confounding factors and BMD, this association was significant for quadriceps and grip strength, These results indicate a major association of an allelic valiant at the VDR locus with muscle strength in elderly nonobese women, which could explain a small association between VDR polymorphism with BMD in the femoral neck in nonobese women, No such associations were found in obese women, suggesting that factors related to obesity obscure such an association.
Notes: LIMBURGS UNIV CTR,DIEPENBEEK,BELGIUM. KATHOLIEKE UNIV LEUVEN,CTR MENSELIJKE ERFELIJKHEID,B-3001 LOUVAIN,BELGIUM. KATHOLIEKE UNIV LEUVEN,DEPT GERIATR,B-3001 LOUVAIN,BELGIUM.Geusens, P, UNIV DIEPENBEEK,DR WILLEMS INST,BLDG C,UNIV CAMPUS,B-3590 DIEPENBEEK,BELGIUM.
URI: http://hdl.handle.net/1942/3252
DOI: 10.1359/jbmr.1997.12.12.2082
ISI #: A1997YJ69800014
ISSN: 0884-0431
Type: Journal Contribution
Appears in Collections: Research publications

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