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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3227

Title: Gamma delta T cell responses to activated T cells in multiple sclerosis patients induced by T cell vaccination
Authors: STINISSEN, Piet
Zhang, JW
VANDEVYVER, Caroline
Hermans, G
RAUS, Jef
Issue Date: 1998
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF NEUROIMMUNOLOGY, 87(1-2). p. 94-104
Abstract: To explore the hypothesis that gamma delta T cells may regulate activated alpha beta T cells, we studied gamma delta T cell responses to alpha beta T cell clones in Multiple Sclerosis (MS) patients who received attenuated autologous autoreactive T cells. We recently conducted a pilot study of T cell vaccination with myelin basic protein reactive T cells in MS. Since T cell vaccination upregulates the anti-vaccine T cell responses, we evaluated gamma delta T cell reactivity towards the vaccine in the vaccinated patients, Lymphocytes were stimulated in vitro with irradiated vaccine cells and the responding lines were checked for the presence of gamma delta T cells. Our data demonstrate that in the majority of vaccinated MS patients gamma delta T cells expand upon stimulation with the vaccine cells. The responding gamma delta T cells were predominantly V delta 1(+)/V gamma 1(+), and represented diverse clonal origins. The gamma delta T cells could not inhibit in vitro proliferation of the vaccine T cells and displayed low cytotoxic reactivity towards the vaccine clones. However, they produced high levels of IL2, TNF alpha and IL10. These results indicate that gamma delta T cells can be stimulated by activated alpha beta T cells, and that these gamma delta T cell responses are upregulaled after T cell vaccination. These findings suggest that gamma delta T cells are involved in peripheral mechanisms to control activated autoreactive T cells. (C) 1998 Elsevier Science B.V. All rights reserved.
Notes: Dr Willems Inst, Multiple Sclerosis Res Unit, B-3590 Diepenbeek, Belgium. Limburgs Univ Centrum, B-3590 Diepenbeek, Belgium. Dr Willems Inst, Biotechnol Unit, B-3590 Diepenbeek, Belgium.Stinissen, P, Dr Willems Inst, Multiple Sclerosis Res Unit, Univ Campus, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/3227
DOI: 10.1016/S0165-5728(98)00060-5
ISI #: 000074768700012
ISSN: 0165-5728
Type: Journal Contribution
Validation: ecoom, 1999
Appears in Collections: Research publications

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