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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3225

Title: Myelin reactive T cells in the autoimmune pathogenesis of multiple sclerosis
Authors: STINISSEN, Piet
Issue Date: 1998
Citation: MULTIPLE SCLEROSIS, 4(3). p. 203-211
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) leading to demyelination. Although it is widely accepted that demyelination in MS results from on active inflammatory process, the cause of the inflammation is still not completely resolved. Findings in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, and observations in human MS have led to the hypothesis that MS is on autoimmune disease mediated by autoreactive T cells with specificity for myelin antigens. The identity of the brain antigen(s) which is (are) the primary target(s) of the autoimmune process is not known, but current evidence indicates that myelin basic protein (MBP) is a likely candidate. In this paper we will overview some of the experimental evidence suggesting that MBP reactive T cells hold a central position in the pathogenesis of MS, and discuss some of the currently tested therapeutic strategies in MS which are directed towards the pathogenic MBP reactive T cells. Although there appears to be no direct correlation between anti-MBP T cell responses and clinical disease activity, some recent observations suggest that monitoring of anti-MBP T cell responses could be helpful to study immunological efficacy of experimental immunotherapies in MS.
Notes: Dr L Willems Inst, B-3590 Diepenbeek, Belgium. Limburgs Univ Ctr, B-3590 Diepenbeek, Belgium.Stinissen, P, Dr L Willems Inst, Univ Campus, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/3225
DOI: 10.1177/135245859800400322
ISI #: 000075396000022
ISSN: 1352-4585
Type: Journal Contribution
Validation: ecoom, 1999
Appears in Collections: Research publications

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