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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3213

Title: Metabolites in feces can be important markers for the abuse of anabolic steroids in cattle
Authors: VAN PUYMBROECK, Mark
LEYSSENS, Luc
VANDERZANDE, Dirk
GELAN, Jan
RAUS, Jef
Issue Date: 1998
Publisher: ROYAL SOC CHEMISTRY
Citation: ANALYST, 123(12). p. 2449-2452
Abstract: In Belgium to control the abuse of anabolic steroids in cattle, urine samples have been gradually replaced by feces samples, because the latter can be obtained more easily from living animals. Urine and feces samples were collected from heifers after administration of boldenone, norethandrolone or ethylestrenol. Metabolites present in feces or urine were determined by GC-MS. Large qualitative and quantitative differences in the metabolic profiles were observed. In feces, in contrast to urine, the parent compounds or their major metabolites were detectable only shortly after administration. On the other hand, metabolites resulting from the reduction of the 3-oxo group and the unsaturated carbon-carbon bonds, present on the A-ring, allow for long-term detection in feces. A-ring reduced metabolites have been identified in samples found positive for norgestrel, boldenone, methylboldenone and methyltestosterone, respectively. These results are in agreement with concomitant in vivo experiments.
Notes: Dr L Willems Inst, Dept Drug & Residue Anal, B-3590 Diepenbeek, Belgium. Limburgs Univ Ctr, Dept SBG, B-3590 Diepenbeek, Belgium.Van Puymbroeck, M, Dr L Willems Inst, Dept Drug & Residue Anal, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/3213
ISI #: 000077607100010
ISSN: 0003-2654
Type: Journal Contribution
Validation: ecoom, 2000
Appears in Collections: Research publications

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