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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/3063

Title: Autoreactive T lymphocytes in multiple sclerosis: pathogenic role and therapeutic targeting
Authors: STINISSEN, Piet
RAUS, Jef
Issue Date: 1999
Publisher: ACTA MEDICA BELGICA
Citation: ACTA NEUROLOGICA BELGICA, 99(1). p. 65-69
Abstract: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), leading to demyelination. Accumulating evidence suggests that MS is an autoimmune disease, mediated by autoreactive T cells with specificity for myelin antigens. The identity of the brain antigens, which are the primary targets of the autoimmune process remains unknown, but myelin basic protein (MBP) is a likely candidate. We will overview some of the experimental evidence, suggesting that MBP reactive T cells hold a central position in the pathogenesis of MS, and discuss how these autoreactive T cells can be therapeutically targeted by T cell vaccination.
Notes: Limburgs Univ Ctr, Dr L Willems Inst, B-3590 Diepenbeek, Belgium.Stinissen, P, Limburgs Univ Ctr, Dr L Willems Inst, Univ Campus, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/3063
ISI #: 000079794900011
ISSN: 0300-9009
Type: Journal Contribution
Validation: ecoom, 2000
Appears in Collections: Research publications

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