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|Title: ||Fluorescent PCDTBT Nanoparticles with Tunable Size for Versatile Bioimaging|
|Authors: ||Cheruku, Srujan|
|Issue Date: ||2019|
|Citation: ||Materials, 12(15) (Art N° 2497)|
|Abstract: ||Conjugated polymer nanoparticles exhibit very interesting properties for use as
bio-imaging agents. In this paper, we report the synthesis of PCDTBT (poly([9-(1’-octylnonyl)-
nanoparticles of varying sizes using the mini-emulsion and emulsion/solvent evaporation approach.
The effect of the size of the particles on the optical properties is investigated using UV-Vis
absorption and fluorescence emission spectroscopy. It is shown that PCDTBT nanoparticles have
a fluorescence emission maximum around 710 nm, within the biological near-infrared “optical
window”. The photoluminescence quantum yield shows a characteristic trend as a function of size.
The particles are not cytotoxic and are taken up successfully by human lung cancer carcinoma A549
cells. Irrespective of the size, all particles show excellent fluorescent brightness for bioimaging.
The fidelity of the particles as fluorescent probes to study particle dynamics in situ is shown as a
proof of concept by performing raster image correlation spectroscopy. Combined, these results show
that PCDTBT is an excellent candidate to serve as a fluorescent probe for near-infrared bio-imaging.|
|ISI #: ||000482576900158|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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|Published version||20.88 MB||Adobe PDF|
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