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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2914

Title: Myelin reactive T cells after T cell vaccination in multiple sclerosis: cytokine profile and depletion by additional immunizations
Authors: Hermans, G
Issue Date: 2000
Citation: JOURNAL OF NEUROIMMUNOLOGY, 102(1). p. 79-84
Abstract: Pathogenic autoreactive T cells can be targeted by T cell vaccination (TCV), a procedure in which patients are immunized with autologous attenuated pathogenic T cells. We reported previously that TCV with myelin basic protein (MBP) reactive T cell clones in multiple sclerosis (MS) patients induced T cell immune responses, resulting in a clonal depletion of MBP reactive T cells in all patients. Five years after TCV, MBP reactive T cells were observed in five out of nine MS patients. These clones had a different clonal origin from those isolated before vaccination. We have studied the cytokine profile, cytotoxicity and epitope specificity of these reappearing clones. Our data indicate that the clones express similar effector functions as those isolated before TCV, suggesting that they also could play a pathogenic role in the disease. We demonstrated that these clones can be depleted by an additional sequence of immunizations. These findings may be relevant to other T cell targeted immunotherapies for MS and other autoimmune diseases. (C) 2000 Elsevier Science B.V. All rights reserved.
Notes: Limburgs Univ Ctr, Dr L Willems Inst, Autoimmune Dis Unit, B-3590 Diepenbeek, Belgium.Stinissen, P, Limburgs Univ Ctr, Dr L Willems Inst, Autoimmune Dis Unit, Univ Campus, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/2914
DOI: 10.1016/S0165-5728(99)00157-5
ISI #: 000084545400011
ISSN: 0165-5728
Category: A1
Type: Journal Contribution
Validation: ecoom, 2001
Appears in Collections: Research publications

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