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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28962

Title: Sensorimotor cortex neurometabolite levels as correlate of motorperformance in normal aging: evidence from a 1H-MRS study
Authors: Levin, Oron
Weerasekera, Akila
King, Bradley
Heise, Kirstin F.
Sima, Diana M.
Chalavi, Sima
Maes, Celine
Peeters, Ronald
Sunaert, Stefan
Cuypers, Koen
Van Huffel, Sabine
Mantini, Dante
Himmelreich, Uwe
Swinnen, Stephan P.
Issue Date: 2019
Citation: NEUROIMAGE, 202 (Art N° 116050)
Abstract: Aging is associated with gradual alterations in the neurochemical characteristics of the brain, which can be assessed in-vivo with proton-magnetic resonance spectroscopy (1H-MRS). However, the impact of these age-related neurochemical changes on functional motor behavior is still poorly understood. Here, we address this knowledge gap and specifically focus on the neurochemical integrity of the left sensorimotor cortex (SM1) and the occipital lobe (OCC), as both regions are main nodes of the visuomotor network underlying bimanual control. 1H-MRS data and performance on a set of bimanual tasks were collected from a lifespan (20–75 years) sample of 86 healthy adults. Results indicated that aging was accompanied by decreased levels of N-acetylaspartate (NAA), glutamate-glutamine (Glx), creatine ​+ ​phosphocreatine (Cr) and myo-inositol (mI) in both regions, and decreased Choline (Cho) in the OCC region. Lower NAA and Glx levels in the SM1 and lower NAA levels in the OCC were related to poorer performance on a visuomotor bimanual coordination task, suggesting that NAA could serve as a potential biomarker for the integrity of the motor system supporting bimanual control. In addition, lower NAA, Glx, and mI levels in the SM1 were found to be correlates of poorer dexterous performance on a bimanual dexterity task. These findings highlight the role for 1H-MRS to study neurochemical correlates of motor performance across the adult lifespan.
Notes: Levin, O (reprint author), Katholieke Univ Leuven, Dept Movement Sci, Movement Control & Neuroplastic Res Grp, Tervuurse Vest 101, B-3001 Leuven, Belgium. oron.levin@kuleuven.be
URI: http://hdl.handle.net/1942/28962
DOI: 10.1016/j.neuroimage.2019.116050
ISSN: 1053-8119
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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