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|Title: ||Structural damage and inflammation on radiographs or magnetic resonance imaging are associated with cortical interruptions on high-resolution peripheral quantitative computed tomography: a study in finger joints of patients with rheumatoid arthritis and healthy subjects|
|Authors: ||Scharmga, A.|
van den Bergh, J. P.
van Rietbergen, B.
van Tubergen, A.
|Issue Date: ||2018|
|Publisher: ||TAYLOR & FRANCIS LTD|
|Citation: ||Scandinavian journal of rheumatology (Trykt. utg.), 47(6), p. 431-439|
|Abstract: ||Objectives: To study the relationship between structural damage and inflammatory features on magnetic resonance imaging (MRI) or radiography and other risk factors [anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) seropositivity, hand dominance, disease duration] and the presence or number of cortical interruptions in finger joints on high-resolution peripheral quantitative computed tomography (HR-pQCT). Method: Finger joints of 38 healthy subjects and 39 patients with rheumatoid arthritis (RA) were examined through radiographs, MRI, and HR-pQCT. Radiographs were scored according to the Sharp/van der Heijde (SvH) method; MRI for the presence of cortical interruptions, bone marrow oedema (BMO), and synovitis; and HR-pQCT images for cortical interruptions. Descriptive statistics were calculated and associations examined using generalized estimating equations. Results: Cortical interruptions were found in healthy subjects and patients with RA on HR-pQCT (mean +/- sd 0.33 +/- 0.63 vs 0.38 +/- 0.64 per joint quadrant, respectively, p < 0.01). Structural damage on MRI (cortical interruptions) or radiographs (SvH >= 1) was associated with the presence of cortical interruptions on HR-pQCT [odds ratio (OR) 12.4, 95% confidence interval (CI) 7.5-21.4, p < 0.01 and OR 4.8, 95% CI 1.9-11.7, respectively, p < 0.01]. The presence of BMO or synovitis was associated with more cortical interruptions on HR-pQCT (beta 0.47, 95% CI 0.4-0.6, p < 0.01 and beta 1.9, 95% CI 0.6-3.1, p < 0.01). In patients with RA, ACPA, and/or RF seropositivity, hand dominance and disease duration were not associated with more cortical interruptions on HR-pQCT. Conclusion: Structural damage and inflammatory features on MRI and radiographs are associated with cortical interruptions on HR-pQCT. No association between other risk factors and cortical interruptions was demonstrated.|
|Notes: ||[Scharmga, A.; Geusens, P.; Peters, M.; van den Bergh, J. P.; Schoonbrood, T.; Vosse, D.; van Tubergen, A.] Maastricht Univ, Med Ctr, Div Rheumatol, Dept Med, POB 5800, NL-6202 AZ Maastricht, Netherlands. [Scharmga, A.; Peters, M.; van den Bergh, J. P.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [Scharmga, A.; Geusens, P.; Peters, M.; van Tubergen, A.] Maastricht Univ, CAPHRI Care & Publ Hlth Res Inst, Maastricht, Netherlands. [Geusens, P.; van den Bergh, J. P.] Viecuri Med Ctr, Dept Internal Med, Venlo, Netherlands. [van den Bergh, J. P.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Loeffen, D.; Weijers, R.] Maastricht Univ, Med Ctr, Dept Radiol, Maastricht, Netherlands. [van Rietbergen, B.] Eindhoven Univ Technol, Dept Biomed Engn, Eindhoven, Netherlands. [van Rietbergen, B.] Maastricht Univ, Med Ctr, Dept Orthopaed Surg, Maastricht, Netherlands.|
|ISI #: ||000451689300001|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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