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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2873

Title: Randomized designs for early trials of new cancer treatments - An overview
Authors: BUYSE, Marc
Issue Date: 2000
Citation: DRUG INFORMATION JOURNAL, 34(2). p. 387-396
Abstract: This paper argues that randomization should more often be considered for early trials of experimental cancer treatments. Uncontrolled as well as randomized designs for Phase II trials are reviewed The severe limitations of uncontrolled designs are illustrated, and possible difficulties with randomized designs discussed. It is argued that in randomized Phase II trials, the treatment allocation method should be chosen to achieve good balance with respect to the most important prognostic factors.
Notes: Int Inst Drug Dev ID2, B-1050 Brussels, Belgium. Limburgs Univ Ctr, Diepenbeek, Belgium.Buyse, M, Int Inst Drug Dev ID2, 430 Ave Louise,B14, B-1050 Brussels, Belgium.
URI: http://hdl.handle.net/1942/2873
ISI #: 000087220200007
ISSN: 0092-8615
Category: A1
Type: Journal Contribution
Validation: ecoom, 2001
Appears in Collections: Research publications

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