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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28695

Title: Outcomes of the amphilimus-eluting polymer-free stent for chronic total occlusion treatment: a multicentre experience
Authors: Maeremans, Joren
Cottens, Daan
Azzalini, Lorenzo
Pereira, Bruno
Godino, Cosmo
Carlino, Mauro
Colombo, Antonio
Frambach, Peter
Bellini, Barbara
Candilio, Luciano
Briguori, Carlo
Pierri, Adele
Lamers, Scott
Roux, Lien
Duponselle, Jolien
Vrolix, Mathias
Dens, Jo
Issue Date: 2018
Citation: Journal of Cardiovascular Medicine, 19(10), p. 564-570
Abstract: AimsLate stent thrombosis and delayed vessel wall healing remain an important issue in coronary vessels treated with drug-eluting stents (DES), especially when long-vessel segments need to be covered, like in chronic total occlusions (CTO). Avoiding polymer use to avoid chronic inflammatory responses is a potential solution to reduce target vessel failure (TVF). We aimed to validate the clinical safety and efficacy at 1 year of the polymer-free Cre8 DES vs. nonpolymer-free DES for the percutaneous treatment of CTO.MethodsBetween September 2011 and August 2016, patients were prospectively enrolled in three CTO centres. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE), including cardiac death, any myocardial infarction, stent thrombosis, TVF and target vessel revascularization.ResultsA total of 102 Cre8 and 133 non-Cre8 patients were enrolled. At 1 year, a low cumulative MACCE was observed in the Cre8 group (6.9%, respectively). Moreover, a numerical trend towards better MACCE was observed in the Cre8 group vs. the non-Cre8 group (6.9 vs. 14.3%; P=0.065). The clinically driven TVF rate was not statistically different between Cre8 and non-Cre8 patients (6.9 vs. 9.8%; P=0.373). A borderline significant difference regarding mortality was observed in favour of Cre8 patients (0 vs. 3.8%; P=0.049).ConclusionLow rates of MACCE and TVF up to 1 year were observed in the Cre8 group, supportive of the use of polymer-free DES for lesions with high complexity.
Notes: [Maeremans, Joren; Cottens, Daan; Vrolix, Mathias; Dens, Jo] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. [Maeremans, Joren; Roux, Lien; Duponselle, Jolien; Dens, Jo] Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium. [Azzalini, Lorenzo; Godino, Cosmo; Carlino, Mauro; Colombo, Antonio; Bellini, Barbara; Candilio, Luciano] Ist Sci San Raffaele, Cardiothorac Vasc Dept, Intervent Cardiol Unit, Milan, Italy. [Pereira, Bruno; Frambach, Peter] Inst Chirurg Cardiaque & Cardiol Intervent, Dept Cardiol, Luxembourg, Luxembourg. [Briguori, Carlo; Pierri, Adele] Clin Mediterranea, Dept Cardiol, Naples, Italy. [Lamers, Scott] Univ Antwerp, Fac Med & Hlth Sci, Antwerp, Belgium.
URI: http://hdl.handle.net/1942/28695
DOI: 10.2459/JCM.0000000000000704
ISI #: 000455660500006
ISSN: 1558-2027
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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