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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28670

Title: Influence of the corticospinal tract wiring pattern on sensorimotor functional connectivity and clinical correlates of upper limb function in unilateral cerebral palsy
Authors: Simon-Martinez, Cristina
Jaspers, Ellen
Alaerts, Kaat
Ortibus, Els
Balsters, Joshua
Mailleux, Lisa
Blommaert, Jeroen
Sleurs, Charlotte
Klingels, Katrijn
Amant, Frederic
Uyttebroeck, Anne
Wenderoth, Nicole
Feys, Hilde
Issue Date: 2019
Publisher: NATURE PUBLISHING GROUP
Citation: Scientific Reports, 9 (Art N° 8230)
Abstract: In children with unilateral cerebral palsy (uCP), the corticospinal tract (CST)-wiring patterns may differ (contralateral, ipsilateral or bilateral), partially determining motor deficits. However, the impact of such CST-wiring on functional connectivity remains unknown. Here, we explored resting-state sensorimotor functional connectivity in 26 uCP with periventricular white matter lesions (mean age (standard deviation): 12.87 m (+/- 4.5), CST wiring: 9 contralateral, 9 ipsilateral, 6 bilateral) compared to 60 healthy controls (mean age (standard deviation): 14.54 (+/- 4.8)), and between CST-wiring patterns. Functional connectivity from each M1 to three bilateral sensorimotor regions of interest (primary sensory cortex, dorsal and ventral premotor cortex) and the supplementary motor area was compared between groups (controls vs. uCP; and controls vs. each CST-wiring group). Seed-to-voxel analyses from bilateral M1 were compared between groups. Additionally, relations with upper limb motor deficits were explored. Aberrant sensorimotor functional connectivity seemed to be CST-dependent rather than specific from all the uCP population: in the dominant hemisphere, the contra lateral CST group showed increased connectivity between M1 and premotor cortices, whereas the bilateral CST group showed higher connectivity between M1 and somatosensory association areas. These results suggest that functional connectivity of the sensorimotor network is CST-wiring-dependent, although the impact on upper limb function remains unclear.
Notes: [Simon-Martinez, Cristina; Alaerts, Kaat; Mailleux, Lisa; Klingels, Katrijn; Feys, Hilde] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium. [Jaspers, Ellen; Balsters, Joshua; Wenderoth, Nicole] ETH, Dept Hlth Sci & Technol, Neural Control Movement Lab, Zurich, Switzerland. [Ortibus, Els] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium. [Balsters, Joshua] Royal Holloway Univ London, Dept Psychol, Egham, Surrey, England. [Blommaert, Jeroen; Sleurs, Charlotte; Amant, Frederic; Uyttebroeck, Anne] Katholieke Univ Leuven, Dept Oncol, Leuven, Belgium. [Klingels, Katrijn] Hasselt Univ, Fac Rehabil Sci, Rehabil Res Ctr, Diepenbeek, Belgium. [Amant, Frederic] Ctr Gynaecol Oncol, Amsterdam, Netherlands. [Amant, Frederic] Univ Amsterdam, Ctr Gynaecol Oncol, Med Ctr, Amsterdam, Netherlands.
URI: http://hdl.handle.net/1942/28670
DOI: 10.1038/s41598-019-44728-9
ISI #: 000469913200010
ISSN: 2045-2322
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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