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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28665

Title: High Salt Inhibits Tumor Growth by Enhancing Anti-tumor Immunity
Authors: Willebrand, Ralf
Hamad, Ibrahim
Van Zeebroeck, Lauren
Kiss, Mate
Bruderek, Kirsten
Geuzens, Anneleen
Swinnen, Dries
Fernandes Corte-Real, Beatriz
Marko, Lajos
Lebegge, Els
Laoui, Damya
Kemna, Josephine
Kammertoens, Thomas
Brandau, Sven
Van Ginderachter, Jo A.
Kleinewietfeld, Markus
Issue Date: 2019
Publisher: FRONTIERS MEDIA SA
Citation: Frontiers in immunology, 10 (Art N° 1141)
Abstract: Excess salt intake could affect the immune system by shifting the immune cell balance toward a pro-inflammatory state. Since this shift of the immune balance is thought to be beneficial in anti-cancer immunity, we tested the impact of high salt diets on tumor growth in mice. Here we show that high salt significantly inhibited tumor growth in two independent murine tumor transplantation models. Although high salt fed tumor-bearing mice showed alterations in T cell populations, the effect seemed to be largely independent of adaptive immune cells. In contrast, depletion of myeloid-derived suppressor cells (MDSCs) significantly reverted the inhibitory effect on tumor growth. In line with this, high salt conditions almost completely blocked murine MDSC function in vitro. Importantly, similar effects were observed in human MDSCs isolated from cancer patients. Thus, high salt conditions seem to inhibit tumor growth by enabling more pronounced anti-tumor immunity through the functional modulation of MDSCs. Our findings might have critical relevance for cancer immunotherapy.
Notes: [Willebrand, Ralf; Hamad, Ibrahim; Van Zeebroeck, Lauren; Geuzens, Anneleen; Swinnen, Dries; Corte-Real, Beatriz Fernandes; Kleinewietfeld, Markus] Univ Hasselt, VIB Ctr Inflammat Res, VIB Lab Translat Immunomodulat, Campus Diepenbeek, Hasselt, Belgium. [Kiss, Mate; Lebegge, Els; Laoui, Damya; Van Ginderachter, Jo A.] Vrije Univ Brussel, Cellular & Mol Immunol Lab, Brussels, Belgium. [Kiss, Mate; Lebegge, Els; Laoui, Damya; Van Ginderachter, Jo A.] VIB Ctr Inflammat Res, Myeloid Cell Immunol Lab, Brussels, Belgium. [Bruderek, Kirsten; Brandau, Sven] Univ Hosp Essen, West German Canc Ctr, Dept Otorhinolaryngol, Res Div, Essen, Germany. [Marko, Lajos] Joint Cooperat Max Delbruck Ctr Mol Med, Expt & Clin Res Ctr, Berlin, Germany. [Marko, Lajos] Charite Univ Med Berlin, Berlin, Germany. [Kemna, Josephine; Kammertoens, Thomas] Charite Univ Med Berlin, Inst Immunol, Berlin, Germany. [Kemna, Josephine; Kammertoens, Thomas] Max Delbruck Ctr Mol Med, Berlin, Germany.
URI: http://hdl.handle.net/1942/28665
DOI: 10.3389/fimmu.2019.01141
ISI #: 000470195500001
ISSN: 1664-3224
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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