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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28602

Title: Visible Light-Mediated Polymerization-Induced Self-Assembly Using Continuous Flow Reactors
Authors: Zaquen, Neomy
Yeow, Jonathan
Junkers, Tanja
Boyer, Cyrille
Zetterlund, Per B.
Issue Date: 2018
Publisher: AMER CHEMICAL SOC
Citation: MACROMOLECULES, 51(14), p. 5165-5172
Abstract: We present the synthesis of polymeric nano-particles of targeted morphology in a continuous process via visible light-mediated aqueous RAFT polymerization-induced self-assembly (PISA). A trithiocarbonate-derived poly-(ethylene glycol) (PEG) macroRAFT was activated in the presence of hydroxypropyl methacrylate (HPMA) at 37 degrees C under blue light irradiation (460 nm), leading to the formation of PEG-b-P(HPMA) nanoparticles. The method is attractive in its simplicity-spheres, worms, and vesicles can easily be obtained in a continuous fashion with higher control in comparison to conventional batch procedures. This allows for more accurate production of particle morphologies and scalable synthesis of these nano-objects. The versatility of this process was demonstrated by the in situ encapsulation of an active compound.
Notes: [Zaquen, Neomy; Yeow, Jonathan; Boyer, Cyrille; Zetterlund, Per B.] Univ New South Wales, CAMD, High St Gate 2, Sydney, NSW 2033, Australia. [Zaquen, Neomy; Yeow, Jonathan; Boyer, Cyrille] Univ New South Wales, Australian Ctr Nanomed, High St Gate 2, Sydney, NSW 2033, Australia. [Zaquen, Neomy; Junkers, Tanja] Univ Hasselt, Organ & Biopolymer Chem OBPC, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Junkers, Tanja] Monash Univ, Sch Chem, Polymer React Design Grp, 19 Rainforest Walk, Melbourne, Vic 3800, Australia.
URI: http://hdl.handle.net/1942/28602
DOI: 10.1021/acs.macromol.8b00887
ISI #: 000440105200017
ISSN: 0024-9297
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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