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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2855

Title: Meta-analysis: Methods, strengths, and weaknesses
Authors: BUYSE, Marc
Piedbois, P
Piedbois, Y
Carlson, RW
Issue Date: 2000
Publisher: P R R INC
Citation: ONCOLOGY-NEW YORK, 14(3). p. 437-443
Abstract: Meta-analysis is a systematic, quantitative approach to the combination of data from several clinical trials that address the same question. This analytic approach can help resolve questions that remain unclear from the results of individual trials. Meta-analysis is of particular interest in oncology because of the small differences in efficacy between therapeutic alternatives. The large number of patients included in meta-analyses permit small to moderate benefits of a treatment to be reliably detected and larger treatment benefits to Be quantified more accurately. Despite these apparent benefits, the use of meta-analysis has met with a great deal of resistance and has generated much controversy in clinical journals, After a brief description of the basic methods of conducting meta-analyses, this article will explore both their advantages and disadvantages.
Notes: Int Inst Drug Dev, B-1050 Brussels, Belgium. Limburgs Univ Ctr, Brussels, Belgium. Hop Henri Mondor, Dept Oncol, F-94010 Creteil, France. Assoc Europeenne Rech Oncol, Creteil, France. Stanford Univ, Med Ctr, Div Oncol, Palo Alto, CA 94304 USA.Buyse, M, Int Inst Drug Dev, 430 Ave Louise,B14, B-1050 Brussels, Belgium.
URI: http://hdl.handle.net/1942/2855
ISI #: 000090128900022
ISSN: 0890-9091
Category: A1
Type: Journal Contribution
Validation: ecoom, 2001
Appears in Collections: Research publications

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