www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28286

Title: Socioeconomic position during pregnancy and DNA methylation signatures at three stages across early life: epigenome-wide association studies in the ALSPAC birth cohort
Authors: Alfano, Rossella
Guida, Florence
Galobardes, Bruna
Chadeau-Hyam, Marc
Delpierre, Cyrille
Ghantous, Akram
Henderson, John
Herceg, Zdenko
Jain, Pooja
Nawrot, Tim
Relton, Caroline
Vineis, Paolo
Castagné, Raphaële
Plusquin, Michelle
Issue Date: 2019
Citation: International journal of epidemiology, 48 (1), p. 30-44
Abstract: Background Socioeconomic experiences are recognized determinants of health, and recent work has shown that social disadvantages in early life may induce sustained biological changes at molecular level that are detectable later in life. However, the dynamics and persistence of biological embedding of socioeconomic position (SEP) remains vastly unexplored. Methods Using the data from the ALSPAC birth cohort, we performed epigenome-wide association studies of DNA methylation changes at three life stages (birth, n = 914; childhood at mean age 7.5 years, n = 973; and adolescence at mean age 15.5 years, n = 974), measured using the Illumina HumanMethylation450 Beadchip, in relation to pregnancy SEP indicators (maternal and paternal education and occupation). Results Across the four early life SEP metrics investigated, only maternal education was associated with methylation levels at birth, and four CpGs mapped to SULF1, GLB1L2 and RPUSD1 genes were identified [false discovery rate (FDR)-corrected P-value <0.05]. No epigenetic signature was found associated with maternal education in child samples, but methylation levels at 20 CpG loci were found significantly associated with maternal education in adolescence. Although no overlap was found between the differentially methylated CpG sites at different ages, we identified two CpG sites at birth and during adolescence which are 219 bp apart in the SULF1 gene that encodes an heparan sulphatase involved in modulation of signalling pathways. Using data from an independent birth cohort, the ENVIRONAGE cohort, we were not able to replicate these findings. Conclusions Taken together, our results suggest that parental SEP, and particularly maternal education, may influence the offspring’s methylome at birth and adolescence.
Notes: Plusquin, M (reprint author), Imperial Coll London, MRC PHE Ctr Environm & Hlth, St Marys Campus,Norfolk Pl, London W2 1PG, England. m.plusquin@imperial.ac.uk
URI: http://hdl.handle.net/1942/28286
DOI: 10.1093/ije/dyy259
ISI #: 000463862500013
ISSN: 0300-5771
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
Published version953.48 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.