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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2799

Title: Histological and immunohistochemical study of the lymphoid tissue in the normal stomach of the gnotobiotic pig
Authors: Driessen, A
Van Ginneken, C
Weyns, A
Geboes, K
Ectors, N
Issue Date: 2002
Citation: VIRCHOWS ARCHIV, 441(6). p. 589-598
Abstract: Animal models have been developed in which the role of Helicobacter pylori in the pathogenesis of different gastroduodenal diseases can be investigated. The gnotobiotic pig was one of the first animal models used. In this model, Helicobacter pylori infection causes gastritis, which shows some similarities to that in humans, such as the development of mucosa-associated lymphoid tissue (MALT). Hence, this animal model can be used to study the development of MALT in the normal stomach. The aim of our study is to see if lymphoid tissue is present or absent in the normal stomach of gnotobiotic pigs before birth and if so, to investigate its development and composition as a function of gestational age and location in the stomach. Therefore, we studied 82 foetal piglets using routine histology and immunohistochemistry. Our findings show that lymphoid tissue is present at birth. It is composed of lymphoid nodules, a diffuse mononuclear infiltrate and intra-epithelial lymphocytes. The development is a sequential process. The lymphoid tissue in the stomach at birth is composed of the immunohistochemically different immunocompetent cells normally present. In conclusion, MALT is present in normal foetal gnotobiotic pig gastric mucosa, and in this model the stomach is no exception to the rest of the gastrointestinal tract.
Notes: Katholieke Univ Leuven Hosp, Dept Pathol, Univ Ziekenhuis St Rafael, B-3000 Louvain, Belgium. Limburgs Univ Ctr, Dept Histol, B-2590 Diepenbeek, Belgium. Univ Antwerp, Dept Morphol Vet Anat Embryol, B-2020 Antwerp, Belgium.Ectors, N, Katholieke Univ Leuven Hosp, Dept Pathol, Univ Ziekenhuis St Rafael, Minderbroedersstr 12, B-3000 Louvain, Belgium.
URI: http://hdl.handle.net/1942/2799
DOI: 10.1007/s00428-002-0651-8
ISI #: 000180042000008
ISSN: 0945-6317
Category: A1
Type: Journal Contribution
Validation: ecoom, 2004
Appears in Collections: Research publications

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