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Title: Hepatic schistosomiasis with massive splenomegaly: a case report and literature review
Authors: Thijs, L.
Messiaen, Peter
Van der Hilst, Jeroen
Madoe, V.
Melis, C.
Van Eyken, P.
Vanmoerkerke, Ignace
Janssens, F.
Issue Date: 2018
Abstract: Schistosomiasis is a parasitic disease caused by Schistosoma species. Intestinal and hepatic schistosomiases are the most common forms of chronic disease. We describe a case of a 26-year old patient from Eritrea who was referred to our hospital with abdominal pain and diarrhea. The diagnosis of hepatosplenic schistosomiasis was made by liver biopsy and the patient was treated with praziquantel. Hepatic schistosomiasis is characterised by deposition of schistosomal eggs in the liver which results in a host cell immune response and leads to granuloma formation and neoangiogenesis. This is hallmarked by different grades of periportal fibrosis with portal hypertension leading to splenomegaly. Normal liver architecture is preserved and periportal fibrosis can be reversible if treated adequately and timely. With a recent native schistosomiasis cluster report from France and the expected influx to Europe of persons from regions endemic for schistosomiasis, increased awareness of this disease in healthcare practitioners is needed. We review the epidemiology, pathogenesis, clinical presentation and treatment of schistosomiasis.
Notes: [Thijs, L.; Vanmoerkerke, I.; Janssens, F.] Jessa Ziekenhuis Hasselt, Dept Gastroenterol & Hepatol, Salvatorstr 20, B-3500 Hasselt, Belgium. [Messiaen, P.; van der Hilst, J.] Jessa Ziekenhuis Hasselt, Dept Infect Dis & Immun, Hasselt, Belgium. [Messiaen, P.; van der Hilst, J.] Hasselt Univ, BIOMED Res Inst, Hasselt, Belgium. [Thijs, L.; Madoe, V.] Jessa Ziekenhuis Hasselt, Dept Haematol, Hasselt, Belgium. [Melis, C.; Van Eyken, P.] Ziekenhuis Oost Limburg Genk, Dept Pathol Anat, Genk, Belgium.
URI: http://hdl.handle.net/1942/27905
ISI #: 000447226500013
ISSN: 1784-3227
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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