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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2785

Title: Spatial determination of successive spikes in the isolated cat duodenum
Authors: Lammers, WJEP
FAES, Christel
Stephen, B
Ver Donck, LV
Schuurkes, JAJ
Issue Date: 2004
Abstract: In seven isolated segments of the feline duodenum, the timings of all spikes and the locations of all spike patches that occurred after 12-16 successive slow waves were analysed. Simultaneous recordings were performed during 1-min periods using 240 extracellular electrodes (24 x 10 array; interelectrode distance 2 mm) positioned onto the serosal surface. In all seven preparations, spikes always occurred during the first half of the slow wave cycle. From preparation to preparation, and within 1-min periods in each preparation, there was limited variation in the spike-spike intervals, in the times between the spikes and the preceding slow wave and in the number of spikes at each electrode site. In contrast, the number of electrode sites that recorded spikes and the number of spike patches both showed great variability between preparations and sometimes within a single preparation. In addition, the location of spikes and spike patches was not random but was significantly concentrated in certain areas, often located along the anti-mesenteric border, while other sites showed little or no spike activity. In conclusion, spikes and spike patches tend to occur significantly in some areas and not in others. This spatial heterogeneity will play a role in intestinal motility.
Notes: UAE Univ, Fac Med & Hlth Sci, Dept Physiol, Al Ain, U Arab Emirates. Limburgs Univ Ctr, Ctr Stat, Diepenbeek, Belgium. Johnson & Johnson Pharmaceut Res & Dev, Dept Biometr & Reporting, Beerse, Belgium. Johnson & Johnson Pharmaceut Res & Dev, Dept Gastrointestinal Pharmacol, Beerse, Belgium.Lammers, WJEP, UAE Univ, Fac Med & Hlth Sci, Dept Physiol, POB 17666, Al Ain, U Arab Emirates.wlammers@smoothmap.org
URI: http://hdl.handle.net/1942/2785
DOI: 10.1111/j.1365-2982.2004.00578.x
ISI #: 000225836700012
ISSN: 1350-1925
Category: A1
Type: Journal Contribution
Validation: ecoom, 2006
Appears in Collections: Research publications

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