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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2783

Title: Effect of chronic airway inflammation and exercise on pulmonary and systemic antioxidant status of healthy and heaves-affected horses
Authors: Kirschvink, N
Smith, N
Fievez, L
Bougnet, V
Art, T.
Degand, G
Marlin, D
Roberts, C
Genicot, B
LINDSEY, Patrick
Lekeux, P
Issue Date: 2002
Citation: EQUINE VETERINARY JOURNAL, 34(6). p. 563-571
Abstract: In heaves-affected horses the relation between oxidant status' airway inflammation (AI) and pulmonary function (PF) is unknown. The oxidant status of blood and pulmonary epithelial lining fluid (PELF) of healthy (H, n = 6) and heaves-affected horses in clinical remission (REM, n 6) and in crisis (CR, n = 7) was assessed at rest, during and after standardised exercise test by measurement of reduced and oxidised glutathione, glutathione redox ratio [GRR %]; uric acid and 8-epi-PGF(2alpha). Oxidant status was related to PF parameters (mechanics of breathing and arterial blood gas tension) and AI parameters (bronchoalveolar lavage [BAL] neutrophil% and AI score). Haemolysate glutathione was significantly different between groups and was correlated with PF and AI parameters; GRR in PELF was increased during CR and was correlated with PF and AI parameters. Exercise induced an increase of plasma uric acid that was significantly higher both in REM and CR. PELF 8-epi-PGF(2alpha) was significantly increased in CR and correlated with PIT and AI parameters. These results suggest that oxidative stress occurring in heaves is correlated with PF and AI and may be locally assessed by PELF glutathione status, uric acid and 8-epi-PGF(2alpha). Systemic repercussions are reflected by assay of GSH in resting horses and by uric acid in exercising horses.
Notes: Univ Liege, Lab Funct Invest, Liege, Belgium. Univ Liege, Fac Vet Med, Lab Anal Foodstuffs Anim Origin, Liege, Belgium. Anim Hlth Trust, Ctr Equine Studies, Newmarket, Suffolk, England. Limburgs Univ Ctr, Diepenbeek, Belgium.Kirschvink, N, Univ Liege, Lab Funct Invest, Liege, Belgium.
URI: http://hdl.handle.net/1942/2783
ISI #: 000178063800005
ISSN: 0425-1644
Category: A1
Type: Journal Contribution
Validation: ecoom, 2003
Appears in Collections: Research publications

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