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|Title: ||Current animal models for the study of congestion in heart failure: an overview|
|Authors: ||Cops, Jirka|
De Moor, Bart
|Issue Date: ||2019|
|Citation: ||HEART FAILURE REVIEWS, 24 (3), p. 387-397|
|Status: ||Early View|
|Abstract: ||Congestion (i.e., backward failure) is an important culprit mechanism driving disease progression in heart failure. Nevertheless, congestion remains often underappreciated and clinicians underestimate the importance of congestion on the pathophysiology of decompensation in heart failure. In patients, it is however difficult to study how isolated congestion contributes to organ dysfunction, since heart failure and chronic kidney disease very often coexist in the so-called cardiorenal syndrome. Here, we review the existing relevant and suitable backward heart failure animal models to induce congestion, induced in the left- (i.e., myocardial infarction, rapid ventricular pacing) or right-sided heart (i.e., aorta-caval shunt, mitral valve regurgitation, and monocrotaline), and more specific animal models of congestion, induced by saline infusion or inferior vena cava constriction. Next, we examine critically how representative they are for the clinical situation. After all, a relevant animal model of isolated congestion offers the unique possibility of studying the effects of congestion in heart failure and the cardiorenal syndrome, separately from forward failure (i.e., impaired cardiac output). In this respect, new treatment options can be discovered.|
|Notes: ||Cops, J (reprint author), Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Inst, Diepenbeek, Belgium.
Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium.
Hasselt Univ, BIOMED, Martelarenlaan 42, B-3500 Hasselt, Belgium.
|ISI #: ||000465250100009|
|Type: ||Journal Contribution|
|Appears in Collections: ||PhD theses|
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|Published version||647.85 kB||Adobe PDF|
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