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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/27569

Title: Short-term effects of physical activity, air pollution and their interaction on the cardiovascular and respiratory system
Authors: Laeremans, Michelle
Dons, Evi
Avila-Palencia, Ione
Carrasco-Turigas, Gloria
Orjuela, Juan Pablo
Anaya, Esther
Cole-Hunter, Tom
de Nazelle, Audrey
Nieuwenhuijsen, Mark
Standaert, Arnout
Van Poppel, Martine
De Boever, Patrick
Panis, Luc Int
Issue Date: 2018
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Citation: ENVIRONMENT INTERNATIONAL, 117, p. 82-90
Abstract: Physical activity (PA) in urban environments may lead to increased inhalation of air pollutants. As PA and air pollution (AP) have respectively beneficial and detrimental effects on the cardiorespiratory system, the responses to these exposures can interact. Therefore, we assessed the short-term effects of PA, AP and their interaction on a set of subclinical cardiovascular and respiratory outcomes in a panel of healthy adults: heart rate variability (HRV), retinal vessel diameters, lung function and fractional exhaled nitric oxide (FeNO). One hundred twenty two participants measured their PA level and exposure to black carbon (BC), a marker of AP exposure, with wearable sensors during an unscripted week in three different seasons. The study was part of the PASTA project in three European cities (Antwerp: 41 participants, Barcelona: 41 participants, London: 40 participants). At the end of each measurement week, the health outcomes were evaluated. Responses to PA, BC and their interaction were assessed with mixed effect regression models. Separate models were used to account for a 2-h and 24-h time window. During the 2-h time window, HRV and lung function changed statistically significantly in response to PA (METhours) and logarithmic BC (%change). Changes in HRV marked an increased sympathetic tone with both PA (logarithmic LF/HF: +7%; p < 0.01) and BC (logarithmic HF: -19%; p < 0.05). In addition, PA provoked bronchodilation which was illustrated by a significant increase in lung function (FEV1: +15.63 mL; p < 0.05). While a BC % increase was associated with a significant lung function decrease (PEF: -0.10 mL; p < 0.05), the interaction indicated a potential protective effect of PA (p < 0.05). We did not observe a response of the retinal vessel diameters. Most subclinical outcomes did not change in the 24-h time window (except for a few minor changes in LF/HF, FeNO and PEF). Our results on the separate and combined effects of short-term PA and AP exposure on subclinical markers of the cardiorespiratory system are relevant for public health. We provide insights on the physiological responses of multiple, complementary markers. This may move further research towards elucidating potential pathways to disease and the long-term clinical impact of the observed physiological changes.
Notes: [Laeremans, Michelle; Dons, Evi; Standaert, Arnout; Van Poppel, Martine; De Boever, Patrick; Panis, Luc Int] Flemish Inst Technol Res VITO, Boeretang 200, B-2400 Mol, Belgium. [Laeremans, Michelle; Panis, Luc Int] Hasselt Univ, Transportat Res Inst IMOB, Wetenschapspk 5-6, B-3590 Diepenbeek, Belgium. [Dons, Evi; De Boever, Patrick] Hasselt Univ, Ctr Environm Sci, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Avila-Palencia, Ione; Carrasco-Turigas, Gloria; Cole-Hunter, Tom; Nieuwenhuijsen, Mark] ISGlobal, Ctr Res Environm Epidemiol, C Dr Aiguader 88, Barcelona 08003, Spain. [Avila-Palencia, Ione; Carrasco-Turigas, Gloria; Cole-Hunter, Tom; Nieuwenhuijsen, Mark] Univ Pompeu Fabra, C Dr Aiguader 88, Barcelona 08003, Spain. [Avila-Palencia, Ione; Carrasco-Turigas, Gloria; Cole-Hunter, Tom; Nieuwenhuijsen, Mark] CIBER Epidemiol & Salud Publ, C Monforte de Lemos 3-5, Madrid 28029, Spain. [Orjuela, Juan Pablo; Anaya, Esther; de Nazelle, Audrey] Imperial Coll London, Ctr Environm Policy, Exhibit Rd,South Kensington Campus, London SW7 2AZ, England. [Cole-Hunter, Tom] Colorado State Univ, Dept Environm & Radiol Hlth Sci, Ft Collins, CO 80523 USA.
URI: http://hdl.handle.net/1942/27569
DOI: 10.1016/j.envint.2018.04.040
ISI #: 000436573400010
ISSN: 0160-4120
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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