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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2711

Title: Reliability of measures of disease activity and disease damage in rheumatoid arthritis: Implications for smallest detectable difference, minimal clinically important difference, and analysis of treatment effects in randomized controlled trials
Authors: Lassere, MND
Johnson, KR
Boers, M
Edmonds, J
Issue Date: 2001
Citation: JOURNAL OF RHEUMATOLOGY, 28(4). p. 892-903
Abstract: We evaluate measurement properties of common rheumatoid arthritis (RA) assessments. Included are a comprehensive literature review and new data on the reliability and smallest detectable difference (SDD) for different classes of these measures. We found that certain common measures such as joint counts, pain, and patient global all had poor reliability and showed large SDD compared to multi-item measures of physical/psychological function or compared to radiographic measures. We discuss the implications of these findings on the use of composite endpoints such as the ACR20 or the EULAR responder index in RA clinical trials, particularly the introduction of misclassification bias that arises from differential measurement error, Finally, we consider generically how the concept of the SDD might or might not relate to the concept of the minimal clinically important difference.
Notes: St George Hosp, Dept Rheumatol, Sydney, NSW, Australia. Univ Hosp Maastricht, Dept Rheumatol, Maastricht, Netherlands. Limburgs Univ Ctr, Diepenbeek, Belgium. US FDA, CDER, Rockville, MD 20857 USA. VU Univ Hosp, Dept Clin Epidemiol, Amsterdam, Netherlands.Lassere, MND, St George Hosp, Dept Rheumatol, Kogarah, NSW 2217, Australia.
URI: http://hdl.handle.net/1942/2711
Link to publication: http://jrheum.com/abstracts/abstracts01/892.html
ISI #: 000167808600041
ISSN: 0315-162X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2002
Appears in Collections: Research publications

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