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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2710

Title: Foundations of the minimal clinically important difference for imaging
Authors: Lassere, MND
Johnson, KR
Issue Date: 2001
Citation: JOURNAL OF RHEUMATOLOGY, 28(4). p. 890-891
Abstract: This article develops a generic conceptual framework for defining and validating the concept of minimal clinically important difference. We propose 3 approaches. The first uses statistical descriptions of the population ("distribution based"), the second relies on experts ("opinion based"), and a third is based on sequential hypothesis formation and testing ("predictive/data driven based"). The first 2 approaches serve as proxies for the third, which is an experimentally driven approach, asking such questions as "What carries the least penalty?" or "What imparts the greatest gain?" As an experimental approach, it has the expected drawbacks, including the need for greater resources, and the need to tolerate trial and error en route. compared to the other 2 models.
Notes: St George Hosp, Dept Rheumatol, Sydney, NSW, Australia. Univ Hosp Maastricht, Dept Rheumatol, Maastricht, Netherlands. Limburgs Univ Ctr, Diepenbeek, Belgium. US FDA, CDER, Rockville, MD 20857 USA.Lassere, MND, St George Hosp, Dept Rheumatol, Kogarah, NSW 2217, Australia.
URI: http://hdl.handle.net/1942/2710
Link to publication: http://jrheum.com/abstracts/abstracts01/890.html
ISI #: 000167808600040
ISSN: 0315-162X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2002
Appears in Collections: Research publications

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