www.uhasselt.be
DSpace

Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26574

Title: Engineering the interface between lipid membranes and nanoporous gold: A study by quartz crystal microbalance with dissipation monitoring
Authors: Losada-Perez, Patricia
Polat, Ozge
Parikh, Atul N.
Seker, Erkin
Renner, Frank Uwe
Issue Date: 2018
Publisher: AMER INST PHYSICS
Citation: BIOINTERPHASES, 13(1) (Art N° 011002)
Abstract: Nanoporous gold (np-Au) is a nanostructured metal with many desirable attributes. Despite the growing number of applications of nanoporous materials, there are still open questions regarding their fabrication and subsequent surface functionalization. For example, the hydrophobic nature of gold surfaces makes the formation of planar supported lipid layers challenging. Here, the authors engineer the interface between np-Au and 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid layers using well-differentiated approaches based on vesicle adsorption and solvent exchange methods. The results reveal that the nanotopography of the np-Au surface plays a clear role in the vesicle adsorption process. Compared to vesicle adsorption, the solvent exchange method proves successful in the formation of planar supported lipid bilayers in both np-Au and planar Au surfaces, being less sensitive to the surface morphological features. The influence of nanostructured surfaces on lipid layer formation is determined by the driving mechanisms behind each process, i.e., the balance of adhesion and cohesion forces in vesicle adsorption and lyotropic lipid phase transitions in solvent exchange, respectively. A better understanding of such interactions will contribute to the development of a variety of applications, from electrochemical biosensors to drug screening and delivery systems, using nanoporous gold coated with stimuli-responsive lipid layers. (C) 2017 Published by the AVS.
Notes: [Losada-Perez, Patricia; Renner, Frank Uwe] Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. [Polat, Ozge; Parikh, Atul N.] Univ Calif Davis, Dept Chem Engn, Davis, CA 95616 USA. [Seker, Erkin] Univ Calif Davis, Dept Elect & Comp Engn, Davis, CA 95616 USA. [Renner, Frank Uwe] IMEC VZW, Div IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. [Losada-Perez, Patricia] Univ Libre Bruxelles, Soft Matter Phys Lab, Campus La Plaine,CP223,Blvd Triomphe, B-1050 Brussels, Belgium.
URI: http://hdl.handle.net/1942/26574
DOI: 10.1116/1.5010249
ISI #: 000419391900001
ISSN: 1934-8630
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
Published version2.57 MBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.