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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26542

Title: ECG Voltage in Relation to Peripheral and Central Ambulatory Blood Pressure
Authors: Yang, Wen-Yi
Mujaj, Blerim
Efremov, Ljupcho
Zhang, Zhen-Yu
Thijs, Lutgarde
Wei, Fang-Fei
Huang, Qi-Fang
Luttun, Aernout
Verhamme, Peter
Nawrot, Tim S.
Boggia, Jose
Staessen, Jan A.
Issue Date: 2018
Citation: AMERICAN JOURNAL OF HYPERTENSION, 31(2), p. 178-187
Abstract: BACKGROUND The heart ejects in the central elastic arteries. No previous study in workers described the diurnal profile of central blood pressure (BP) or addressed the question whether electrocardiogram (ECG) indexes are more closely associated with central than peripheral BP. METHODS In 177 men (mean age, 29.1 years), we compared the associations of ECG indexes with brachial and central ambulatory BP, measured over 24 hours by the validated oscillometric Mobil-O-Graph 24h PWA monitor. RESULTS From wakefulness to sleep, as documented by diaries, systolic/diastolic BP decreased by 11.7/13.1 mm Hg peripherally and 9.3/13.6 mm Hg centrally, whereas central pulse pressure (PP) increased by 4.3 mm Hg (P < 0.0001). Over 24 hours and the awake and asleep periods, the peripheral-minus-central differences in systolic/diastolic BPs averaged 11.8/-1.6, 12.7/-1.8, and 10.3/-1.2 mm Hg, respectively (P < 0.0001). Cornell voltage and index averaged 1.18 mV and 114.8 mV.ms. Per 1-SD increment in systolic/diastolic BP, the Cornell voltages were 0.104/0.086 mV and 0.082/0.105 mV higher in relation to brachial 24-hour and asleep BP and 0.088/0.90 mV and 0.087/0.107 mV higher in relation to central BP. The corresponding estimates for the Cornell indexes were 9.6/8.6 and 8.2/10.5 mV.ms peripherally and 8.6/8.9 and 8.8/10.7 mV.ms centrally. The regression slopes (P = 0.067) and correlation coefficients (P = 0.088) were similar for brachial and central BP. Associations of ECG measurements with awake BP and PP were not significant. CONCLUSIONS Peripheral and central BPs run in parallel throughout the day and are similarly associated with the Cornell voltage and index.
Notes: [Yang, Wen-Yi; Mujaj, Blerim; Efremov, Ljupcho; Zhang, Zhen-Yu; Thijs, Lutgarde; Wei, Fang-Fei; Huang, Qi-Fang; Staessen, Jan A.] Univ Leuven, Fac Med, Studies Coordinating Ctr, KU Leuven Dept Cardiovasc Sci,Res Unit Hypertens, Leuven, Belgium. [Luttun, Aernout; Verhamme, Peter] Univ Leuven, Fac Med, Ctr Mol & Vasc Biol, KU Leuven Dept Cardiovasc Sci, Leuven, Belgium. [Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Boggia, Jose] Univ Republica, Hosp Clin, Ctr Nefrol, Dept Fisiopatol,Unidad Hipertens Arterial, Montevideo, Uruguay. [Staessen, Jan A.] Maastricht Univ, R & D VitaK Grp, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/26542
DOI: 10.1093/ajh/hpx157
ISI #: 000422955700010
ISSN: 0895-7061
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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