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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26541

Title: Potential Impact of Changes in the Schedule for Primary Diphtheria-Tetanus Toxoids-Pertussis Immunization as Control Strategy for Pertussis
Authors: Elena Bergero, Paula
Fabricius, Gabriel
Flavia Hozbor, Daniela
Theeten, Heidi
Hens, Niel
Issue Date: 2018
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: PEDIATRIC INFECTIOUS DISEASE JOURNAL, 37(2), p. e36-e42
Abstract: Background: Pertussis is a vaccine-preventable respiratory disease that may cause death mainly in infants. The schedules for primary pertussis vaccination are set in each country by the local health authorities. Several different schedules meet World Health Organization recommendations, 2-4-6 months, 6-10-14 weeks, 2-3-4 months and 3-4-5 months being the most commonly used worldwide. In this work, we analyze the benefits of changing the vaccination schedule to control the disease. Methods: We used an age-structured deterministic mathematical model for pertussis transmission to compute the incidences for the 4 above-mentioned schedules. Different vaccination coverages and vaccine effectiveness levels were considered. Immunization data from Argentina and Belgium were used. Results: The highest reduction in incidence was obtained by adopting the 6-10-14 weeks schedule, reaching about a 36% reduction of 0-1-year incidence with respect to the 2-4-6 months schedule. We show the dependence of this reduction on both vaccine effectiveness and coverage. The severe pertussis incidence decreased significantly when the first dose of the 2-4-6 months schedule was accelerated to 6 weeks. Finally, we estimated that the communication campaign adopted in Flanders (Belgium) to improve compliance with the vaccine schedule could lead to a reduction of 16% in severe pertussis incidence and about 7% in total incidence in infants. Conclusions: Our work highlights the use of mathematical modeling to quantify the benefits of the existing vaccination schedules and the strategies that could be implemented to improve their compliance. Our results indicated that the 6-10-14 weeks is the best schedule option and that the Belgium vaccination campaign significantly reduced the incidence of severe cases.
Notes: [Elena Bergero, Paula; Fabricius, Gabriel] Univ Nacl La Plata, Fac Ciencias Exactas, Inst Invest Fis Quim Teor & Aplicadas, CC 16,Suc 4, RA-1900 La Plata, Argentina. [Elena Bergero, Paula; Fabricius, Gabriel] Consejo Nacl Invest Cient & Tecn, CCT La Plata, CC 16,Suc 4, RA-1900 La Plata, Argentina. [Flavia Hozbor, Daniela] Univ Nacl La Plata, Fac Ciencias Exactas, Dept Ciencias Biol, Lab VacSal,Inst Biotecnol & Biol Mol, Calles 50 & 115, RA-1900 La Plata, Argentina. [Flavia Hozbor, Daniela] Consejo Nacl Invest Cient & Tecn, CCT La Plata, Calles 50 & 115, RA-1900 La Plata, Argentina. [Theeten, Heidi] Univ Antwerp, Fac Med, Vaccine & Infect Dis Inst, CEV, Campus Drie Eiken,Univ Pl 1, B-2610 Antwerp, Belgium. [Hens, Niel] Univ Antwerp, Fac Med, Vaccine & Infect Dis Inst, CHERMID, Campus Drie Eiken,Univ Pl 1, B-2610 Antwerp, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Martelarenlaan 42, B-3500 Hasselt, Belgium.
URI: http://hdl.handle.net/1942/26541
DOI: 10.1097/INF.0000000000001752
ISI #: 000422929000002
ISSN: 0891-3668
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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