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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26503

Title: Evaluation of vascular healing of polymer-free sirolimus-eluting stents in native coronary artery stenosis: a serial follow-up at three and six months with optical coherence tomography imaging
Authors: Suwannasom, Pannipa
Onuma, Yoshinobu
Benit, Edouard
Gach, Olivier
von Birgelen, Clemens
Hofma, Sjoerd H.
Sotomi, Yohei
Bo, Xu
Zhang, Yao-Jun
Gao, Runlin
Garcia-Garcia, Hector M.
Wykrzykowska, Joanna J.
de Winter, Robbert J.
Serruys, Patrick W.
Issue Date: 2016
Citation: EUROINTERVENTION, 12(5), p. E574-E583
Abstract: Aims: Our aim was to assess vascular response after polymer-free sirolimus-eluting stent (SES) implantation by using an optical coherence tomography (OCT)-derived vascular healing score (HS), quantifying the deficiency of healing. Methods and results: In a prospective, multicentre, single-arm, open-label study, OCT examinations were performed at three months in 45 patients (47 lesions). Per protocol, 24 lesions which had not reached adequate vascular healing according to study criteria were scheduled for OCT examination at six months. The HS was calculated at two time points. Serial OCT imaging demonstrated that the proportion of covered stent struts increased from a median of 87.1% at three months to 98.6% at six months (p< 0.001). The neointimal thickness increased from a median of 82.8 mu m to 112.2 mu m (p< 0.001), whereas the median percentages of malapposed struts were 0.2% and 0.0% at the two respective time points. Neointimal volume obstruction increased from 6.3% to 12.8%, and the HS decreased from a median of 28.1 at three months to 2.4 at six months. Conclusions: In patients who had inadequate vascular healing three months after polymer-free SES implantation, serial OCT showed almost complete vascular healing at six months.
URI: http://hdl.handle.net/1942/26503
DOI: 10.4244/EIJV12I5A97
ISI #: 000394039800009
ISSN: 1774-024X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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