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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26461

Title: Particle Size Control during Ultrasonic Cooling Crystallization of Paracetamol
Authors: Gielen, Bjorn
Claes, Thomas
Janssens, Jonas
Jordens, Jeroen
Thomassen, Leen C. J.
Van Gerven, Tom
Braeken, Leen
Issue Date: 2017
Citation: CHEMICAL ENGINEERING & TECHNOLOGY, 40(7), p. 1300-1308
Abstract: The effect of ultrasound on the crystal size during cooling crystallization of paracetamol was investigated. Sonication was enabled in three distinct stages to define the operating guidelines for crystal size control. In addition, it was identified whether size reduction results from a higher amount of nuclei upon primary nucleation or from enhanced secondary nucleation. The results show that tuning of the ultrasonic power density and exposure time after nucleation results in crystal sizes between 70 and 140 mm. In contrast, the use of ultrasound before nucleation does not affect the size, indicating enhanced secondary nucleation as the main mechanism. Finally, sonication after complete desupersaturation reduces the crystal size by about 30 mm but causes surface erosion.
URI: http://hdl.handle.net/1942/26461
DOI: 10.1002/ceat.201600647
ISI #: 000405290700014
ISSN: 0930-7516
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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