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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26456

Title: An observational time and motion study of denosumab subcutaneous injection and zoledronic acid intravenous infusion in patients with metastatic bone disease: results from three European countries
Authors: Body, Jean-Jacques
Gatta, Francesca
De Cock, Erwin
Tao, Sunning
Kritikou, Persefoni
Wimberger, Pauline
Mebis, Jeroen
Peeters, Marc
Pedrazzoli, Paolo
Caraceni, Augusto
Adamo, Vincenzo
Hechmati, Guy
Issue Date: 2017
Citation: SUPPORTIVE CARE IN CANCER, 25(9), p. 2823-2832
Abstract: Purpose Denosumab (administered via subcutaneous injection) demonstrated superior efficacy versus the intravenously administered zoledronic acid in the prevention of skeletal-related events in an integrated analysis of three head-to-head phase III trials in patients with bone metastases secondary to solid tumors. To date, no studies have evaluated treatment administration duration endpoints of these two agents. Methods A multinational, multi-site, observational time and motion study conducted in 10 day oncology units (DOUs) across Belgium, Germany, and Italy. Observations of process time included task time and active healthcare professional (HCP) time for pre-defined tasks. Patient time measurements included entering/exiting the DOU, treatment room, and treatment chair or examination table. Results A total of 189 patients were enrolled (82 received zoledronic acid and 107 received denosumab) and 238 observations were recorded (104 for zoledronic acid and 134 for denosumab). Mean total task time was reduced by 81% when denosumab was used versus zoledronic acid (8.4 versus 44.2 min; p < 0.0001; pooled analysis across all countries). Pooled estimates for active HCP time were 12.2 min for zoledronic acid and 6.9 min for denosumab (44% reduction; p < 0.0001). Conclusions In the countries studied, using denosumab compared with zoledronic acid reduced total task time and active HCP time. Thus, HCPs have more time to dedicate to other patients or care activities. An ability to increase the volume of appointments within DOUs could reduce waiting lists in sites operating at full capacity and increase overall productivity and efficiency in hospital processes.
URI: http://hdl.handle.net/1942/26456
DOI: 10.1007/s00520-017-3697-5
ISI #: 000406340400019
ISSN: 0941-4355
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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