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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26434

Title: Muscle carnosine in experimental autoimmune encephalomyelitis and multiple sclerosis
Authors: Keytsman, Charly
Blancquaert, Laura
Wens, Inez
Missine, Maarten
Van Noten, Pieter
Vandenabeele, Frank
Derave, Wim
Eijnde, Bert O.
Issue Date: 2018
Abstract: Background: Muscle carnosine is related to contractile function (Ca+ + handling) and buffering of exercise-induced acidosis. As these muscular functions are altered in Multiple Sclerosis (MS) it is relevant to understand muscle carnosine levels in MS. Methods: Tibialis anterior muscle carnosine was measured in an animal MS model (EAE, experimental autoimmune encephalomyelitis, n = 40) and controls (CONEX, n = 40) before and after exercise training (EAE(EX), CONEX, 10d, 1 h/d, 24 m/min treadmill running) or sedentary conditions (EAE(SED), CONSED). Human m. vastus lateralis carnosine of healthy controls (HC, n = 22) and MS patients (n = 24) was measured. Results: EAE muscle carnosine levels were decreased (p < .0001) by similar to 40% to similar to 64% at 10d and 17d following EAE induction (respectively) regardless of exercise (p = .823). Similarly, human MS muscle carnosine levels were decreased (- 25%, p = .03). Conclusion: Muscle carnosine concentrations in an animal MS model and MS patients are substantially reduced. In EAE exercise therapy does not restore this.
Notes: Keytsman, C (reprint author), Agoralaan Bldg A, B-3590 Diepenbeek, Belgium. charly.keytsman@uhasselt.be
URI: http://hdl.handle.net/1942/26434
DOI: 10.1016/j.msard.2018.02.013
ISI #: 000432725300007
ISSN: 2211-0348
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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