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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/26432

Title: Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis
Authors: Majdinasab, Nastaran
Motl, Robert W.
Mokhtarzade, Motahare
Zimmer, Philipp
Ranjbar, Rouholah
Keytsman, Charly
Cullen, Tom
Negaresh, Raoof
Baker, Julien S.
Issue Date: 2018
Abstract: Objective: To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS). Methods: Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise. Results: Levels of IL-10 and TNF-alpha in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-alpha levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups. Conclusion: After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance. (C) 2018 Elsevier Ltd. All rights reserved.
Notes: Mokhtarzade, M (reprint author), Ahvaz Jundishapur Univ Med Sci, Sch Med, Musculoskeletal Rehabil Res Ctr, Ahwaz, Iran. mz.mokhtarzade@yahoo.com
URI: http://hdl.handle.net/1942/26432
DOI: 10.1016/j.ctcp.2018.03.004
ISI #: 000432520800044
ISSN: 1744-3881
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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